Eur J Clin Invest 2011
Background Left ventricular (LV) diastolic dysfunction has great effects on the left atrium (LA). A recently developed electromechanical interval (PA-TDI), which was determined as the time interval from the initiation of P wave deflection to the peak of local lateral LA tissue Doppler imaging signal, was reported to be associated with LA electrophysiological properties. The goal of our study was to evaluate the association between the PA-TDI interval and LV diastolic function.
Materials and methods A total of 224 consecutive patients were enrolled. LV diastolic dysfunction was defined as either (i) impaired relaxation: E/A ratio < 0·75 and E/E′ ratio < 10, (ii) pseudonormal pattern: 0·75 ≤ E/A ratio < 1·5 and E/E′ ratio > 10 or (iii) restrictive pattern: E/A ratio ≥ 1·5 and E/E′ ratio > 10. The PA-TDI intervals were measured and compared between patients with and without diastolic dysfunction.
Results Fifty-six per cent of the study population had abnormal diastolic function. The PA-TDI interval was significantly longer in the diastolic dysfunction group than that in the normal group (147·8 ± 18·2 vs. 130·4 ± 17·0 ms, P < 0·01). In patients with diastolic dysfunction, the PA-TDI intervals became progressively longer as the diastolic dysfunction progressed from impaired relaxation (141·2 ± 11·4 ms), pseudonormal pattern (147·6 ± 18·0 ms) to restrictive pattern (164·1 ± 20·9 ms).
Conclusions The PA-TDI interval was significantly longer in patients with LV diastolic dysfunction than those without it. Its prolongation may reflect the severity of atrial remodelling because of the abnormal diastolic function of LV.