The CCR5Δ32 allele is associated with reduced liver inflammation in hepatitis C virus infection


Amnon Peled, Hadassah University Hospital, Gene Therapy Institute, PO Box 12000, Jerusalem, Israel. Tel.: 972 2 677 8780; Fax: 972 2 643 0982; E-mail:


CCR5Δ32 is a deletion mutation in the chemokine receptor CCR5. Liver inflammatory activity was found to be significantly reduced (P = 0.005) in Jewish Israeli patients infected with the hepatitis C virus (HCV) carrying the CCR5Δ32 allele. The CCR5Δ32 allele does not alter susceptibility to HCV infection; however, it may play a role in the progression and outcome of the disease.