These authors contributed equally to this work.
The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila
Article first published online: 28 FEB 2006
Genes to Cells
Volume 11, Issue 4, pages 397–407, April 2006
How to Cite
Brun, S., Vidal, S., Spellman, P., Takahashi, K., Tricoire, H. and Lemaitre, B. (2006), The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Genes to Cells, 11: 397–407. doi: 10.1111/j.1365-2443.2006.00953.x
Communicated by: Konrad Basler
- Issue published online: 28 FEB 2006
- Article first published online: 28 FEB 2006
- Received: 18 October 2005 Accepted: 27 December 2005
Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-regulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila.