The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors’ Organization


Prof K. J. Pasi, Chairman of the UKHCDO von Willebrand's Disease Working Party, Department of Haematology, Barts and The London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, UK.
Tel.: +44 20 7377 7000 (x3152); fax: +44 709 222 7649;


Summary.  von Willebrand disease (VWD) is the commonest inherited bleeding disorder. However, despite an increasing understanding of the pathophysiology of VWD, the diagnosis of VWD is frequently difficult because of uncertainty regarding the relationship between laboratory assays and function in vivo. The objective of this guideline is to provide contemporary advice on a rational approach to the diagnosis of VWD. This is the second edition of this UK Haemophilia Centre Doctors’ Organisation (UKHCDO) guideline and supersedes the previous edition which was published in 1997.