The pharmacokinetics of coagulation factors


Martin Lee, UCLA School of Public Health, 3944 Eureka Drive, Los Angeles, CA 91604, USA.
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Summary.  In this article, we provide a summary of the generally accepted approaches to the design and analysis of studies examining the pharmacokinetic (PK) profile of an infused coagulation factor in patients with a deficiency of one or more of these factors. Furthermore, we briefly review the known PK results for various commercially available coagulation factor preparations under single and continuous infusion.