• 1
    Schuster V, Seregard S. Ligneous conjunctivitis. Surv Ophthalmol 2003; 48: 36988.
  • 2
    Owen CA Jr. Fibrinolysis and thrombolysis. In: NicholsWL, BowieEJW, eds. A History of Blood Coagulation, Rochester, MN: Mayo Foundation for Medical Education and Research, 2001: 8796.
  • 3
    Aoki N, Moroi M, Sakata Y, Yoshida N, Matsuda M. Abnormal plasminogen: a hereditary molecular abnormality found in a patient with recurrent thrombosis. J Clin Invest 1978; 61: 118695.
  • 4
    Robbins KC. Dysplasminogenemias. Prog Cardiovasc Dis 1992;34:295308.
  • 5
    Mingers AM, Heimburger N, Zeitler P, Kreth HW, Schuster V. Homozygous type I plasminogen deficiency. Semin Thromb Hemost 1997; 23: 25969.
  • 6
    Tait RC, Walker ID, Conkie JA, Islam SI, McCall F. Isolated familial plasminogen deficiency may not be a risk factor for thrombosis. Thromb Haemost 1996; 76: 10048.
  • 7
    Dykes D, Polesky H. Incidence of the PLG *Q0 allele in human populations. In: MayrW, ed. Advanced in Forensic Haemogenetics, Berlin: Springer, 1988: 2614.
  • 8
    Weidinger S, Patutschnick W, Schwarzfischer F. Further evidence of a silent plasminogen (PLG) allele in two paternity cases. Z Rechtsmed 1988; 101: 99104.
  • 9
    Okamoto A, Sakata T, Mannami T et al. Population-based distribution of plasminogen activity and estimated prevalence and relevance to thrombotic diseases of plasminogen deficiency in the Japanese: the Suita Study. J Thromb Haemost 2003; 1: 2397403.
  • 10
    Tefs K, Gueorguieva M, Klammt J et al. Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients. Blood 2006; 108: 30216.
  • 11
    Ooe A, Kida M, Yamazaki T et al. Common mutations of plasminogen detected in three Asian populations by an amplification refractory mutation system and rapid automated capillary electrophoresis. Thromb Haemost 1999; 82: 13426.
  • 12
    Booth NA, Bachmann F. Plasminogen-plasmin system. In: ColemanRW, MarderVJ, ClowesAW, GeorgeJN, GoldhaberSZ, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice, Philadelphia: Lippincott Williams & Wilkins, 2006: 33564.
  • 13
    Li WY, Chong SS, Huang EY, Tuan TL. Plasminogen activator/plasmin system: a major player in wound healing? Wound Repair Regen 2003; 11: 23947.
  • 14
    Coleman RW, Marder VJ, Clowes AW. Overview of coagulation, fibrinolysis, and their regulation. In: ColemanRW, MarderVJ, ClowesAW, GeorgeJN, GoldhaberSZ, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice, Philadelphia: Lippincott Williams & Wilkins; 2006:1720.
  • 15
    Eagle RC Jr, Brooks JS, Katowitz JA, Weinberg JC, Perry HD. Fibrin as a major constituent of ligneous conjunctivitis. Am J Ophthalmol 1986; 101: 4934.
  • 16
    McGrand JC, Rees DM, Harry J. Ligneous conjunctivitis. Br J Ophthalmol 1969; 53: 37381.
  • 17
    Kraft J, Lieb W, Zeitler P, Schuster V. Ligneous conjunctivitis in a girl with severe type I plasminogen deficiency. Graefes Arch Clin Exp Ophthalmol 2000; 238: 797800.
  • 18
    Ozcelik U, Akcoren Z, Anadol D et al. Pulmonary involvement in a child with ligneous conjunctivitis and homozygous type I plasminogen deficiency. Pediatr Pulmonol 2001; 32: 17983.
  • 19
    Pantanowitz L, Bauer K, Tefs K et al. Ligneous (pseudomembranous) inflammation involving the female genital tract associated with type-1 plasminogen deficiency. Int J Gynecol Pathol 2004; 23: 2925.
  • 20
    Schuster V, Zeitler P, Seregard S et al. Homozygous and compound-heterozygous type I plasminogen deficiency is a common cause of ligneous conjunctivitis. Thromb Haemost 2001; 85: 100410.
  • 21
    Schuster V, Mingers AM, Seidenspinner S et al. Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis. Blood 1997; 90: 95866.
  • 22
    Schuster V, Seidenspinner S, Zeitler P et al. Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis. Blood 1999; 93: 345766.
  • 23
    Scully C, Gokbuget AY, Allen C et al. Oral lesions indicative of plasminogen deficiency (hypoplasminogenemia). Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 91: 3347.
  • 24
    Drew AF, Kaufman AH, Kombrinck KW et al. Ligneous conjunctivitis in plasminogen-deficient mice. Blood 1998; 91: 161624.
  • 25
    Ploplis VA, Carmeliet P, Vazirzadeh S et al. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation 1995; 92: 258593.
  • 26
    Siboni SM, Spreafico M, Menegatti M, Martinelli I, Peyvandi F. Molecular characterization of an Italian patient with plasminogen deficiency and ligneous conjunctivitis. Blood Coagul Fibrinolysis 2007; 18: 814.
  • 27
    Tefs K, Tait CR, Walker ID et al. A K19E missense mutation in the plasminogen gene is a common cause of familial hypoplasminogenaemia. Blood Coagul Fibrinolysis 2003; 14: 4116.
  • 28
    Rodriguez-Ares MT, Abdulkader I, Blanco A et al. Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. Virchows Arch 2007; 451: 81521.
  • 29
    Diamond JP, Chandna A, Williams C et al. Tranexamic acid-associated ligneous conjunctivitis with gingival and peritoneal lesions. Br J Ophthalmol 1991; 75: 7534.
  • 30
    Toker H, Toker MI, Goze F, Turgut M, Yilmaz A. A ligneous periodontitis and conjunctival lesions in a patient with plasminogen deficiency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103: e358.
  • 31
    Pantanowitz L. Ligneous cervicitis. BJOG 2004; 111: 635.
  • 32
    Shigekiyo T, Kanazuka M, Aihara K et al. No increased risk of thrombosis in heterozygous congenital dysplasminogenemia. Int J Hematol 2000; 72: 24752.
  • 33
    McColl MD, Tait RC, Walker ID et al. Asymptomatic coinheritance of heterozygous plasminogen deficiency and the factor V Leiden mutation. Blood Coagul Fibrinolysis 1997; 8: 1959.
  • 34
    Sartori MT, Simioni P, Patrassi GM et al. Combined heterozygous plasminogen deficiency and factor V Leiden defect in the same kindred. Clin Appl Thromb Hemost 2000; 6: 3640.
  • 35
    Preist JR, Ramsay NK, Bennett AJ et al. The effect of L-asparaginase on antithrombin, plasminogen, and plasma coagulation during therapy for acute lymphoblastic leukemia. J Pediatr 1982; 100: 9905.
  • 36
    Smith CD, Latortue R, McFarland JG, Menitove JE. Plasminogen deficiency and thrombosis after plasmapheresis therapy for multiple sclerosis. Neurology 1986; 36: 14101.
  • 37
    Schuster V, Seidenspinner S, Muller C, Rempen A. Prenatal diagnosis in a family with severe type I plasminogen deficiency, ligneous conjunctivitis and congenital hydrocephalus. Prenat Diagn 1999; 19: 4837.
  • 38
    Watts P, Suresh P, Mezer E et al. Effective treatment of ligneous conjunctivitis with topical plasminogen. Am J Ophthalmol 2002; 133: 4515.
  • 39
    Teresa SM, Saggiorato G, Pellati D et al. Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis. Thromb Haemost 2003; 90: 8691.
  • 40
    Silva GB, Bariani C, Mendonca EF, Batista AC. Clinical manifestations due to severe plasminogen deficiency: a case report. J Dent Child 2006; 73: 17982.
  • 41
    Heidemann DG, Williams GA, Hartzer M, Ohanian A, Citron ME. Treatment of ligneous conjunctivitis with topical plasmin and topical plasminogen. Cornea 2003; 22: 7602.
  • 42
    Schott D, Dempfle CE, Beck P et al. Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency. N Engl J Med 1998; 339: 167986.