Endocrine differentiation in mucoid carcinoma of the breast

Authors

  • C. CAPELLA,

    1. Departments of Histopathology, The Royal Postgraduate Medical School, London, England, The University of Bologna Medical School and the University of Pavia at Varese, Italy
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  • V. EUSEBI,

    1. Departments of Histopathology, The Royal Postgraduate Medical School, London, England, The University of Bologna Medical School and the University of Pavia at Varese, Italy
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  • B. MANN,

    1. Departments of Histopathology, The Royal Postgraduate Medical School, London, England, The University of Bologna Medical School and the University of Pavia at Varese, Italy
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  • J. G. AZZOPARDI

    Corresponding author
    1. Departments of Histopathology, The Royal Postgraduate Medical School, London, England, The University of Bologna Medical School and the University of Pavia at Varese, Italy
      Address for correspondence: Professor J.G.Azzopardi, Department of Histopathology, Royal Postgraduate Medical School, Ducane Road, London W12 oHS.
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Address for correspondence: Professor J.G.Azzopardi, Department of Histopathology, Royal Postgraduate Medical School, Ducane Road, London W12 oHS.

Abstract

Mucoid carcinoma of the breast is not a single homogeneous entity. It comprises two main variants separable on structural and cytological grounds and a smaller transitional type. The salient pathological differences are detailed. One variant is usually arygrophilic and contains dense core granules of the type seen in endocrine tumours. Both endocrine and amphicrine cells have been identified in this subtype. The relationship of this endocrine variant of mucoid carcinoma to other argyrophil carcinomas (so-called ‘carcinoids’) of the breast is discussed.

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