Tie-1 tyrosine kinase expression in human thyroid neoplasms
Article first published online: 26 MAR 2004
Volume 44, Issue 4, pages 318–322, April 2004
How to Cite
Ito, Y., Yoshida, H., Uruno, T., Nakano, K., Takamura, Y., Miya, A., Kobayashi, K., Yokozawa, T., Matsuzuka, F., Kuma, K. and Miyauchi, A. (2004), Tie-1 tyrosine kinase expression in human thyroid neoplasms. Histopathology, 44: 318–322. doi: 10.1111/j.1365-2559.2003.01805.x
- Issue published online: 26 MAR 2004
- Article first published online: 26 MAR 2004
- Date of submission 25 March 2003 Accepted for publication 10 July 2003
Aims: To investigate tie-1 expression in human thyroid neoplasms. Recent studies have demonstrated that receptor-type tyrosine kinases (RTKs) contribute to carcinoma progression. Tie-1 is one of the RTKs and plays a role in angiogenesis, although its pathophysiological significance in human carcinoma is still to be elucidated.
Methods and results: Immunohistochemical expression of tie-1 was studied in various thyroid neoplasms. Tie-1 immunoreactivity was only occasionally observed in normal follicular cells. In papillary carcinoma, tie-1 was classified as positive in carcinoma cells in 55.7% of the cases and was more frequently expressed in those of smaller size with an absence of a poorly differentiated lesion. In contrast, tie-1 was positive in only 8.3% of anaplastic carcinoma and no cases of follicular carcinoma or adenoma were positive.
Conclusions: These results suggest that tie-1 has a role in thyroid tumorigenesis, especially in the early phase of papillary carcinoma, but it is not important in the progression of anaplastic carcinoma or follicular tumour.