Caveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastases
Article first published online: 9 JUL 2009
© 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Limited
Volume 55, Issue 1, pages 20–27, July 2009
How to Cite
Cassoni, P., Daniele, L., Maldi, E., Righi, L., Tavaglione, V., Novello, S., Volante, M., Scagliotti, G. V. and Papotti, M. (2009), Caveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastases. Histopathology, 55: 20–27. doi: 10.1111/j.1365-2559.2009.03326.x
- Issue published online: 9 JUL 2009
- Article first published online: 9 JUL 2009
- Date of submission 12 August 2008 Accepted for publication 16 December 2008
- adrenal metastasis;
- brain metastasis;
- lung carcinoma;
Aims: To study caveolin-1 (Cav-1) expression in metastatic lung carcinomas.
Methods and results: Cav-1 expression was investigated in a series of 121 lung carcinomas and it was shown that 18/121 tumours (14.9%) were Cav-1+. None of the pure bronchioloalveolar carcinomas proved to be positive, vs. 42.8% of the large cell carcinomas (neuroendocrine subtype excluded). Adenocarcinomas (8.5%), large cell neuroendocrine carcinomas (20%) and squamous cell carcinomas (29.6%) displayed an intermediate percentage of positive cases, suggesting a gradient of Cav-1 expression according to tumour histotype-related aggressiveness. Moreover, the percentage of Cav-1+ tumours with distant metastases was almost double that of non-metastatic tumours (17.8% vs. 8.1%), irrespective of the histotype. In 34 tumours metastatic to the brain, primary and secondary lesions were compared and 53% of brain metastases were Cav-1+ vs. 20.6% of primaries, indicating a de novo acquisition of Cav-1 expression. This pattern was exclusive to the brain, as it was not acquired in adrenal metastases. In our series, the presence of epidermal growth factor receptor amplification, determined by fluorescence in situ hybridization, was not related to Cav-1 reactivity.
Conclusions: Cav-1 immunoreactivity in lung carcinoma is histotype-dependent and acquired de novo in brain metastases, suggesting a site-specific phenotypic shift in secondary lesions.