Sebaceous neoplasia and the Muir–Torre syndrome: important connections with clinical implications

Authors

  • Sara C Shalin,

    1. Department of Pathology, Baylor College of Medicine, Houston, TX, 1Department of Cancer Biology, University of Massachusetts Medical Center, Worcester, MA, USA, 2St John’s Institute of Dermatology, St Thomas’ Hospital, London, UK, and 3Departments of Pathology and Dermatology, Section of Dermatopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
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  • Stephen Lyle,

    1. Department of Pathology, Baylor College of Medicine, Houston, TX, 1Department of Cancer Biology, University of Massachusetts Medical Center, Worcester, MA, USA, 2St John’s Institute of Dermatology, St Thomas’ Hospital, London, UK, and 3Departments of Pathology and Dermatology, Section of Dermatopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
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  • 1 Eduardo Calonje,

    1. Department of Pathology, Baylor College of Medicine, Houston, TX, 1Department of Cancer Biology, University of Massachusetts Medical Center, Worcester, MA, USA, 2St John’s Institute of Dermatology, St Thomas’ Hospital, London, UK, and 3Departments of Pathology and Dermatology, Section of Dermatopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
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  • and 2 Alexander J F Lazar 3

    1. Department of Pathology, Baylor College of Medicine, Houston, TX, 1Department of Cancer Biology, University of Massachusetts Medical Center, Worcester, MA, USA, 2St John’s Institute of Dermatology, St Thomas’ Hospital, London, UK, and 3Departments of Pathology and Dermatology, Section of Dermatopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
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Alexander Lazar, MD, PhD, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd- Unit 85, Houston, TX 77030-5009, USA.
e-mail: alazar@mdanderson.org

Abstract

Shalin S C, Lyle S, Calonje E & Lazar A J F
(2010) Histopathology56, 133–147
Sebaceous neoplasia and the Muir–Torre syndrome: important connections with clinical implications

Sebaceous neoplasia comprises a spectrum ranging from benign to malignant. Proper histological identification is important for treatment, prognosis and potential association with the Muir–Torre syndrome (MTS). Our increased understanding of the significance and pathogenesis of these tumours has led to improved risk stratification, screening recommendations, and treatment of patients with an initial presentation of a sebaceous tumour. This review focuses on the diagnostic and histological features of sebaceous lesions, the MTS, and recent insights into the molecular pathogenesis of sebaceous tumours.

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