Clear-cell papillary renal cell carcinoma: 24 cases of a distinct low-grade renal tumour and a comparative genomic hybridization array study of seven cases
Article first published online: 27 JUN 2011
© 2011 Blackwell Publishing Limited
Volume 58, Issue 7, pages 1064–1071, June 2011
How to Cite
Adam, J., Couturier, J., Molinié, V., Vieillefond, A. and Sibony, M. (2011), Clear-cell papillary renal cell carcinoma: 24 cases of a distinct low-grade renal tumour and a comparative genomic hybridization array study of seven cases. Histopathology, 58: 1064–1071. doi: 10.1111/j.1365-2559.2011.03857.x
- Issue published online: 27 JUN 2011
- Article first published online: 27 JUN 2011
- Date of submission 28 October 2010 Accepted for publication 11 February 2010
- clear-cell papillary renal cell carcinoma;
- renal tumour
Adam J, Couturier J, Molinié V, Vieillefond A & Sibony M (2011) Histopathology58, 1064–1071 Clear-cell papillary renal cell carcinoma: 24 cases of a distinct low-grade renal tumour and a comparative genomic hybridization array study of seven cases
Aims: To report clinicopathological and genomic characteristics of (ccpRCC), a rare, recently characterized renal tumour entity.
Methods and results: Twenty-four renal tumours identified as ccpRCC were collected. Data from comparative genomic hybridization on microarrays (array-CGH) were obtained for seven of these. Most tumours (58%) occurred in the absence of renal disease. Mean patient age was 58.1 years. Tumours were small (mean size: 2.4 cm) and classified as pT1. Histological characteristics consisted of tubules and papillae lined by a single layer of small clear cells harbouring low-grade nuclei (Fuhrman grades 1 or 2). Architectural variations, with compact areas (41% of cases) and a micro- or macrocystic pattern (67% of cases) were observed frequently. Immunostaining demonstrated diffuse, strong expression of cytokeratin 7 and vimentin, whereas CD10, racemase, RCC antigen, translocation factor E3, TFE3 and translocation factor EB were consistently negative. In seven tumours, array-CGH detected no chromosomal imbalances.
Conclusions: Clear-cell papillary renal cell carcinoma (ccpRCC) were differentiated from other renal neoplasms by a specific constellation of histopathological and immunohistochemical features, without characteristic genomic imbalances. Clinical, histopathological and genomic data suggested that these tumours have a low potential for malignancy.