• Please log in or register to access this feature.

IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas

  1. Brunangelo Falini1,
  2. Claudio Agostinelli2,
  3. Barbara Bigerna1,
  4. Alessandra Pucciarini1,
  5. Roberta Pacini1,
  6. Alessia Tabarrini1,
  7. Flavio Falcinelli1,
  8. Milena Piccioli2,
  9. Marco Paulli3,
  10. Marcello Gambacorta4,
  11. Maurilio Ponzoni5,
  12. Enrico Tiacci1,
  13. Stefano Ascani6,
  14. Maria Paola Martelli1,
  15. Riccardo Dalla Favera7,
  16. Harald Stein8,
  17. Stefano A Pileri2

Article first published online: 20 JUN 2012

DOI: 10.1111/j.1365-2559.2012.04289.x

Issue

Histopathology

Histopathology

Volume 61, Issue 5, pages 930–941, November 2012

Additional Information

How to Cite

Falini, B., Agostinelli, C., Bigerna, B., Pucciarini, A., Pacini, R., Tabarrini, A., Falcinelli, F., Piccioli, M., Paulli, M., Gambacorta, M., Ponzoni, M., Tiacci, E., Ascani, S., Martelli, M. P., Favera, R. D., Stein, H. and Pileri, S. A. (2012), IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas. Histopathology, 61: 930–941. doi: 10.1111/j.1365-2559.2012.04289.x

Author Information

  1. 1

    Institute of Haematology, University of Perugia, Ospedale S. Maria della Misericordia, Perugia

  2. 2

    Department of Haematology and Clinical Oncology ‘L. and A. Seràgnoli’, Haemopathology Unit, University of Bologna, Policlinico S. Orsola, Bologna, Italy

  3. 3

    Department of Paediatric Sciences and Human and Hereditary Pathology, Pathologic Anatomy Section, Pavia University, Policlinico S. Matteo, Pavia

  4. 4

    Department of Laboratory Medicine, Ospedale Niguarda Ca’, Granda

  5. 5

    Pathology Unit, Department of Oncology, University Scientific Institute San Raffaele, Milan

  6. 6

    Institute of Pathology, University of Terni, Terni, Italy

  7. 7

    Institute for Cancer Genetics, Columbia University, New York, NY, USA

  8. 8

    Berlin Reference and Consultation Centre for Lymphoma and Haematopathology, Pathodiagnostik Berlin, Berlin, Germany

*B Falini, Institute of Haematology, University of Perugia, Strada Sant’Andrea delle Fratte, 06126, Perugia, Italy. e-mail: faliniem@unipg.it

Publication History

  1. Issue published online: 25 OCT 2012
  2. Article first published online: 20 JUN 2012
  3. Accepted manuscript online: 4 APR 2012 06:13AM EST
  4. Date of submission 27 February 2012 Accepted for publication 28 March 2012

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (3468K)

Keywords:

  • immunohistochemistry;
  • IRTA1;
  • marginal zone lymphomas;
  • monoclonal antibodies

Falini B, Agostinelli C, Bigerna B, Pucciarini A, Pacini R, Tabarrini A, Falcinelli F, Piccioli M, Paulli M, Gambacorta M, Ponzoni M, Tiacci E, Ascani S, Martelli M P, Dalla Favera R, Stein H & Pileri S A (2012) Histopathology 61, 930–941

IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas

Aims:  The aim of this study was to search for a molecule selectively expressed by marginal zone (MZ) lymphomas (MZLs), whose diagnosis is currently based on morphological criteria and negativity for markers detectable in other B-cell lymphomas.

Methods and results:  Two thousand one hundred and four peripheral lymphomas of various types were immunostained with a monoclonal antibody against immunoglobulin superfamily receptor translocation-associated 1 (IRTA1), which recognizes the equivalents of MZ in human lymphoid tissues other than spleen. IRTA1 expression was restricted to extranodal (93%) and nodal MZLs (73%) and to lymphomas with MZ differentiation. Extranodal MZL cells with the strongest IRTA1 expression were usually located adjacent to epithelia, mimicking the IRTA1 expression pattern of normal and acquired mucosa-associated lymphoid tissue (MALT). The cytological features, growth pattern and IRTA1 positivity in nodal MZLs suggest they may derive from IRTA1+ perifollicular B cells or monocytoid B cells detectable in reactive lymph nodes. Double immunostaining for IRTA1/bcl-6 tracked the colonization of B-cell follicles by MZL cells, and showed modulation of their phenotype (e.g. acquisition of bcl-6) during recirculation through germinal centres. MZL cells differentiating into plasma cells usually lost IRTA1.

Conclusions:  These results further expand our knowledge of the biology of MZLs, and highlight IRTA1 as the first positive marker for MZLs, enabling more accurate diagnosis of these neoplasms.

View Full Article with Supporting Information (HTML) Get PDF (3468K)