Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes
Article first published online: 14 MAY 2004
Volume 112, Issue 2, pages 165–176, June 2004
How to Cite
Ivetic, A. and Ridley, A. J. (2004), Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology, 112: 165–176. doi: 10.1111/j.1365-2567.2004.01882.x
- Issue published online: 14 MAY 2004
- Article first published online: 14 MAY 2004
- Received 16 March 2004; accepted 23 March 2004.
- adhesion molecules;
- signalling: signal transduction;
- cell polarity;
The ezrin/radixin/moesin (ERM) family of actin-binding proteins act both as linkers between the actin cytoskeleton and plasma membrane proteins and as signal transducers in responses involving cytoskeletal remodelling. The Rho family of GTPases also regulate cytoskeletal organisation, and several molecular pathways linking ERM proteins and Rho GTPases have been described. This review discusses recent findings on ERM protein function in leucocytes and how these may be integrated with Rho GTPase signalling.