The potential for Toll-like receptors to collaborate with other innate immune receptors


Prof. S. Gordon, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK. E-mail: (Secretary).


Cells of the innate immune system express a large repertoire of germ-line encoded cell-surface glycoprotein receptors including Toll-like receptors (TLRs). TLRs recognize conserved motifs on microbes and induce inflammatory signals. Evidence suggests that individual members of the TLR family or other non-TLR surface antigens either physically or functionally interact with each other and cumulative effects of these interactions instruct the nature and outcome of the immune response to a particular pathogen.