• 1
    Savill J, Fadok V. Corpse clearance defines the meaning of cell death. Nature 2000; 407: 7848.
  • 2
    Fadok VA, Bratton DL, Henson PM. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest 2001; 108: 95762.
  • 3
    Hengartner MO. Apoptosis: corralling the corpses. Cell 2001; 104: 3258.
  • 4
    Henson PM, Bratton DL, Fadok VA. The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol 2001; 2: 62733.
  • 5
    Henson PM, Bratton DL, Fadok VA. Apoptotic cell removal. Curr Biol 2001; 11: R795805.
  • 6
    Hamon Y, Chambenoit O, Chimini G. ABCA1 and the engulfment of apoptotic cells. Biochim Biophys Acta 2002; 1585: 6471.
  • 7
    Manfredi AA, Iannacone M, D'Auria F, Rovere-Querini P. The disposal of dying cells in living tissues. Apoptosis 2002; 7: 15361.
  • 8
    Savill J, Dransfield I, Gregory CD, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2002; 2: 96575.
  • 9
    Kim SJ, Gershov D, Ma X, Brot N, Elkon KB. Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses. Ann NY Acad Sci 2003; 987: 6878.
  • 10
    Grimsley C, Ravichandran KS. Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals. Trends Cell Biol 2003; 13: 64856.
  • 11
    Rovere-Querini P, Dumitriu IE. Corpse disposal after apoptosis. Apoptosis 2003; 8: 46979.
  • 12
    Albert ML. Death-defying immunity: do apoptotic cells influence antigen processing and presentation? Nat Rev Immunol 2004; 4: 22331.
  • 13
    Hart SP, Smith JR, Dransfield I. Phagocytosis of opsonized apoptotic cells: roles for ‘old-fashioned’ receptors for antibody and complement. Clin Exp Immunol 2004; 135: 1815.
  • 14
    Maderna P, Godson C. Phagocytosis of apoptotic cells and the resolution of inflammation. Biochim Biophys Acta 2003; 1639: 14151.
  • 15
    Van den Eijnde SM, Boshart L, Reutelingsperger CPM, De Zeeuw CI, Vermeij-Keers C. Phosphatidylserine plasma membrane asymmetry in vivo: a pancellular phenomenon which alters during apoptosis. Cell Death Diff 1997; 4: 3116.
  • 16
    Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 23957.
  • 17
    Leers MP, Bjorklund V, Bjorklund B, Jornvall H, Nap M. An immunohistochemical study of the clearance of apoptotic cellular fragments. Cell Mol Life Sci 2002; 59: 135865.
  • 18
    Cao WM, Murao K, Imachi H et al. Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. J Mol Endocrinol 2004; 32: 497505.
  • 19
    Bursch W, Taper HS, Lauer B, Schulte-Hermann R. Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia. Virchows Arch B Cell Pathol Mol Pathol 1985; 50: 15366.
  • 20
    Dogusan Z, Montecino-Rodriguez E, Dorshkind K. Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells. J Immunol 2004; 172: 471723.
  • 21
    Wood W, Turmaine M, Weber R, Camp V, Maki RA, McKercher SR, Martin P. Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryos. Development 2000; 127: 524552.
  • 22
    Parnaik R, Raff MC, Scholes J. Differences between the clearance of apoptotic cells by professional and non-professional phagocytes. Curr Biol 2000; 10: 85760.
  • 23
    Knepper-Nicolai B, Savill J, Brown SB. Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspases. J Biol Chem 1998; 273: 305306.
  • 24
    Eda S, Yamanaka M, Beppu M. Carbohydrate-mediated phagocytic recognition of early apoptotic cells undergoing transient capping of CD43 glycoprotein. J Biol Chem 2004; 279: 596774.
  • 25
    Devitt A, Pierce S, Oldreive C, Shingler WH, Gregory CD. CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidyiserine. Cell Death Diff 2003; 10: 37182.
  • 26
    Albert ML, Pearce SFA, Francisco LM, Sauter B, Roy P, Silverstein RL, Bhardwaj N. Immature dendritic cells phagocytose apoptotic cells via alpha (v) beta (5) and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 1998; 188: 135968.
  • 27
    Ronchetti A, Rovere P, Iezzi G et al. Immunogenicity of apoptotic cells in vivo. Role of antigen load, antigen-presenting cells, and cytokines. J Immunol 1999; 163: 1306.
  • 28
    Savill J, Dransfield I, Hogg N, Haslett C. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 1990; 343: 1703.
  • 29
    Savill J, Hogg N, Ren Y, Haslett C. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest 1992; 90: 151322.
  • 30
    Brown S, Heinisch I, Ross E, Shaw K, Buckley CD, Savill J. Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 2002; 418: 2003.
  • 31
    Ogden CA, De Cathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001; 194: 78195.
  • 32
    Devitt A, Moffatt OD, Raykundalia C, Capra JD, Simmons DL, Gregory CD. Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 1998; 392: 5059.
  • 33
    Dini L. Recognizing death: liver phagocytosis of apoptotic cells. Eur J Histochem 2000; 44: 21727.
  • 34
    Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekowitz RAB, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 2000; 405: 8590.
  • 35
    Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992; 148: 220716.
  • 36
    Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002; 417: 1827.
  • 37
    Franc NC, White K, Ezekowitz RAB. Phagocytosis and development: back to the future. Curr Opin Immunol 1999; 11: 4752.
  • 38
    Gregory CD. CD14-dependent clearance of apoptotic cells: relevance to the immune system. Curr Opin Immunol 2000; 12: 2734.
  • 39
    Janeway CA. Approaching the asymptote − evolution and revolution in immunology. Cold Spring Harbor Symp Quant Biol 1989; 54: 113.
  • 40
    Medzhitov R, Janeway CA. Innate immunity. The virtues of a nonclonal system of recognition. Cell 1997; 91: 2958.
  • 41
    Pugin J, Heumann D, Tomasz A et al. CD14 is a pattern recognition receptor. Immunity 1994; 1: 50916.
  • 42
    Fadok VA, De Cathelineau A, Daleke DL, Henson PM, Bratton DL. Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. J Biol Chem 2001; 276: 10717.
  • 43
    Kagan VE, Gleiss B, Tyurina YY et al. A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol 2002; 169: 48799.
  • 44
    Anderson HA, Englert R, Gursel I, Shacter E. Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine. Cell Death Diff 2002; 9: 61625.
  • 45
    Arur S, Uche UE, Rezaul K, Fong M, Scranton V, Cowan AE, Mohler W, Han DK. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Devel Cell 2003; 4: 58798.
  • 46
    Fujii C, Shiratsuchi A, Manaka J, Yonehara S, Nakanishi Y. Difference in the way of macrophage recognition of target cells depending on their apoptotic states. Cell Death Diff 2001; 8: 111322.
  • 47
    Navratil JS, Watkins SC, Wisnieski JJ, Ahearn JM. The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells. J Immunol 2001; 166: 32319.
  • 48
    Li M, Carpio DF, Zheng Y, Bruzzo P, Singh V, Ouaaz F, Medzhitov RM, Beg AA. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol 2001; 166: 712835.
  • 49
    Shiratsuchi A, Watanabe I, Takeuchi O, Akira S, Nakanishi Y. Inhibitory effect of toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages. J Immunol 2004; 172: 203947.
  • 50
    Gregory CD, Devitt A. CD14 and apoptosis. Apoptosis 1999; 4: 1120.
  • 51
    Huynh ML, Fadok VA, Henson PM. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 2002; 109: 4150.
  • 52
    Gershov D, Kim S, Brot N, Elkon KB. C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med 2000; 192: 135363.
  • 53
    Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, Nagata S. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 2004; 304: 114750.
  • 54
    Hoffmann PR. DeCathelineau AM Ogden CA et al. Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J Cell Biol 2001; 155: 64959.
  • 55
    Tada K, Tanaka M, Hanayama R, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1. J Immunol 2003; 171: 571826.
  • 56
    Hu B, Sonstein J, Christensen PJ, Punturieri A, Curtis JL. Deficient in vitro and in vivo phagocytosis of apoptotic T cells by resident murine alveolar macrophages. J Immunol 2000; 165: 212433.
  • 57
    Hanayama R, Tanaka M, Miwa K, Nagata S. Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells. J Immunol 2004; 172: 387682.
  • 58
    Pickering MC, Fischer S, Lewis MR, Walport MJ, Botto M, Cook HT. Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice. J Invest Dermatol 2001; 117: 528.
  • 59
    Bijl M, Horst G, Bijzet J, Bootsma H, Limburg PC, Kallenberg CG. Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages. Arthritis Rheum 2003; 48: 24854.
  • 60
    Nauta AJ, Raaschou-Jensen N, Roos A et al. Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol 2003; 33: 285363.
  • 61
    Clissold PM, Ponting CP. JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Trends Biochem Sci 2001; 26: 79.
  • 62
    Cui P, Qin B, Liu N, Pan G, Pei D. Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Exp Cell Res 2004; 293: 15463.
  • 63
    Kurosaka K, Takahashi M, Watanabe N, Kobayashi Y. Silent cleanup of very early apoptotic cells by macrophages. J Immunol 2003; 171: 46729.
  • 64
    Meagher LC, Savill JS, Baker A, Fuller RW, Haslett C. Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane-b2. J Leuk Biol 1992; 52: 26973.
  • 65
    Stern M, Savill J, Haslett C. Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis − mediation by alpha (v) beta (3)/cd36/thrombospondin recognition mechanism and lack of phlogistic response. Am J Pathol 1996; 149: 91121.
  • 66
    Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J Clin Invest 1998; 101: 8908.
  • 67
    Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I. Immunosuppressive effects of apoptotic cells. Nature 1997; 390: 3501.
  • 68
    McDonald PP, Fadok VA, Bratton D, Henson PM. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. J Immunol 1999; 163: 616472.
  • 69
    Fadok VA, Bratton DL, Henson PM. Identification of a novel gene that mediates phosphatidylserine recognition and anti-inflammatory activity in macrophages ingesting apoptotic cells. Cold Spring Harbor Laboratory Abstracts of Programmed Cell Death Meeting, 1999 2004; 64.
  • 70
    Parente L, Solito E. Annexin 1: more than an anti-phospholipase protein. Inflamm Res 2004; 53: 12532.
  • 71
    Latour S, Tanaka H, Demeure C et al. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. J Immunol 2001; 167: 254754.
  • 72
    Oshima K, Ruhul Amin AR, Suzuki A, Hamaguchi M, Matsuda S. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett 2002; 519: 17.
  • 73
    Lemke G, Lu Q. Macrophage regulation by Tyro 3 family receptors. Curr Opin Immunol 2003; 15: 316.
  • 74
    Gao YK, Herndon JM, Zhang H, Griffith TS, Ferguson TA. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J Exp Med 1998; 188: 88796.
  • 75
    Chen WJ, Frank ME, Jin WW, Wahl SM. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001; 14: 71525.
  • 76
    Szondy Z, Sarang Z, Molnar P et al. Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Proc Natl Acad Sci USA 2003; 100: 78127.
  • 77
    Byrne A, Reen DJ. Lipopolysaccharide induces rapid production of IL-10 by monocytes in the presence of apoptotic neutrophils. J Immunol 2002; 168: 196877.
  • 78
    Fadok VA, Bratton DL, Guthrie L, Henson PM. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol 2001; 166: 684754.
  • 79
    Vandivier RW, Fadok VA, Hoffmann PR et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 2002; 109: 66170.
  • 80
    Brouckaert G, Kalai M, Krysko DV et al. Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production. Mol Biol Cell 2004; 15: 1089100.
  • 81
    Cocco RE, Ucker DS. Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure. Mol Biol Cell 2001; 12: 91930.
  • 82
    Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 1915.
  • 83
    Bianchi ME, Manfredi A. Chromatin and cell death. Biochim Biophys Acta 2004; 1677: 1816.
  • 84
    Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004; 279: 73707.
  • 85
    Hart SP, Alexander KM, Dransfield I. Immune complexes bind preferentially to FcgammaRIIA (CD32) on apoptotic neutrophils, leading to augmented phagocytosis by macrophages and release of proinflammatory cytokines. J Immunol 2004; 172: 18827.
  • 86
    Muhl H, Nold M, Chang JH, Frank S, Eberhardt W, Pfeilschifter J. Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells. Eur J Immunol 1999; 29: 322535.
  • 87
    Uchimura E, Watanabe N, Niwa O, Muto M, Kobayashi Y. Transient infiltration of neutrophils into the thymus in association with apoptosis induced by whole-body X-irradiation. J Leukoc Biol 2000; 67: 7804.
  • 88
    Kawagishi C, Kurosaka K, Watanabe N, Kobayashi Y. Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo. Biochim Biophys Acta Mol Cell Res 2001; 1541: 22130.
  • 89
    Kurosaka K, Takahashi M, Kobayashi Y. Activation of extracellular signal-regulated kinase 1/2 is involved in production of CXC-chemokine by macrophages during phagocytosis of late apoptotic cells. Biochem Biophys Res Commun 2003; 306: 10704.
  • 90
    Lorimore SA, Coates PJ, Wright EG. Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation. Oncogene 2003; 22: 705869.
  • 91
    Lucas M, Stuart LM, Savill J, Lacy-Hulbert A. Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion. J Immunol 2003; 171: 26105.
  • 92
    Freire, -d, E-Lima CG, Nascimento DO et al. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Nature 2000; 403: 199203.
  • 93
    Balanco JMD, Moreira MEC, Bonomo A, Bozza PT, Amarante-Mendes G, Pirmez C, Barcinski MA. Apoptotic mimicry by an obligate intracellular parasite downregulates macrophage microbicidal activity. Curr Biol 2001; 11: 18703.
  • 94
    Ribeiro-Gomes FL, Otero AC, Gomes NA et al. Macrophage interactions with neutrophils regulate Leishmania major infection. J Immunol 2004; 172: 445462.
  • 95
    Horino K, Nishiura H, Ohsako T, Shibuya Y, Hiraoka T, Kitamura N, Yamamoto T. A monocyte chemotactic factor, S19 ribosomal protein dimer, in phagocytic clearance of apoptotic cells. Lab Invest 1998; 78: 60377.
  • 96
    Segundo C, Medina F, Rodriguez C, Martinez-Palencia R, Leyva-Cobian F, Brieva JA. Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Blood 1999; 94: 101220.
  • 97
    Lauber K, Bohn E, Krober SM et al. Apoptotic cells induce migration of phagocytes via caspase-3- mediated release of a lipid attraction signal. Cell 2003; 113: 71730.
  • 98
    Ellis RE, Jacobson DM, Horvitz HR. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics 1991; 129: 7994.
  • 99
    Gumienny TL, Hengartner MO. How the worm removes corpses: the nematode C-elegans as a model system to study engulfment. Cell Death Diff 2001; 8: 5648.
  • 100
    Wu YC, Horvitz HR. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 1998; 392: 5014.
  • 101
    Tosello-Trampont AC, Brugnera E, Ravichandran KS. Evidence for a conserved role for CrkII and Rac in engulfment of apoptotic cells. J Biol Chem 2001; 276: 13797802.
  • 102
    Su HP, Nakada-Tsukui K, Tosello-Trampont AC, Li Y, Bu G, Henson PM, Ravichandran KS. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem 2002; 277: 117729.
  • 103
    Grimsley CM, Kinchen JM, Tosello-Trampont AC et al. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol Chem 2004; 279: 608797.
  • 104
    Wang X, Wu YC, Fadok VA et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003; 302: 15636.
  • 105
    Botto MI, Agnola C, Bygrave AE et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 1998; 19: 569.
  • 106
    Hamon Y, Broccardo C, Chambenoit O et al. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol 2000; 2: 399406.
  • 107
    Platt N, Suzuki H, Kodama T, Gordon S. Apoptotic thymocyte clearance in scavenger receptor class A- deficient mice is apparently normal. J Immunol 2000; 164: 48617.
  • 108
    Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS, Matsushima GK. Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 2001; 411: 20711.
  • 109
    Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA. Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 2003; 302: 15603.
  • 110
    Taylor PR, Carugati A, Fadok VA et al. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 2000; 192: 35966.
  • 111
    Cohen PL, Caricchio R, Abraham V et al. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 2002; 196: 13540.
  • 112
    Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 131730.
  • 113
    Cocca BA, Cline AM, Radic MZ. Blebs and apoptotic bodies are B cell autoantigens. J Immunol 2002; 169: 15966.
  • 114
    Potter PK, Cortes-Hernandez J, Quartier P, Botto M, Walport MJ. Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells. J Immunol 2003; 170: 322332.
  • 115
    Licht R, Jacobs CW, Tax WJ, Berden JH. No constitutive defect in phagocytosis of apoptotic cells by resident peritoneal macrophages from pre-morbid lupus mice. Lupus 2001; 10: 1027.
  • 116
    Licht R, Dieker JW, Jacobs CW, Tax WJ, Berden JH. Decreased phagocytosis of apoptotic cells in diseased SLE mice. J Autoimmun 2004; 22: 13945.
  • 117
    Brown SB, Savill J. Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes. J Immunol 1999; 162: 4805.
  • 118
    Duffield JS, Erwig LP, Wei XQ, Liew FY, Rees AJ, Savill JS. Activated macrophages direct apoptosis and suppress mitosis of mesangial cells. J Immunol 2000; 164: 21109.
  • 119
    Reddien PW, Cameron S, Horvitz HR. Phagocytosis promotes programmed cell death in C. elegans. Nature 2001; 412: 198202.
  • 120
    Hoeppner DJ, Hengartner MO, Schnabel R. Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 2001; 412: 2026.
  • 121
    Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4: 718.
  • 122
    Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J et al. Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol 2004; 172: 340614.
  • 123
    Christiansen-Weber TA, Voland JR, Wu Y, Ngo K, Roland BL, Nguyen S, Peterson PA, Fung-Leung WP. Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency. Am J Pathol 2000; 157: 101729.
  • 124
    Sano H, Hsu DK, Apgar JR, Yu L, Sharma BB, Kuwabara I, Izui S, Liu FT. Critical role of galectin-3 in phagocytosis by macrophages. J Clin Invest 2003; 112: 38997.
  • 125
    Kunisaki Y, Masuko S, Noda M, Inayoshi A, Sanui T, Harada M, Sasazuki T, Fukui Y. Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor. Blood 2004; 103: 33624.