• 1
    See D, Mason S, Roshan R. Increased tumor necrosis factor alpha (TNF-alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers. Immunol Invest 2002; 31: 13753.DOI: 10.1081/IMM-120004804
  • 2
    Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 2004; 14: 58994.DOI: 10.1111/j.1048-891X.2004.14403.x
  • 3
    Kawagishi H, Inagaki R, Kanao T, Mizuno T, Shimura K, Ito H, Hagiwara T, Nakamura T. Fractionation and antitumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies. Carbohydr Res 1989; 186: 26773.DOI: 10.1016/0008-6215(89)84040-6
  • 4
    Ito H, Shimura K, Itoh H, Kawade M. Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) ‘Himematsutake’ and its mechanisms in tumor-bearing mice. Anticancer Res 1997; 17: 27784.
  • 5
    Fujimiya Y, Suzuki Y, Oshiman K et al. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol Immunother 1998; 46: 14759.DOI: 10.1007/s002620050473
  • 6
    Ebina T, Fujimiya Y. Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Biotherapy 1998; 11: 25965.
  • 7
    Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H. Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. Biochem Mol Biol Int 1999; 47: 70714.
  • 8
    Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 2001; 131: 140913.
  • 9
    Ohno N, Furukawa M, Miura NN, Adachi Y, Motoi M, Yadomae T. Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Biol Pharm Bull 2001; 24: 8208.DOI: 10.1248/bpb.24.820
  • 10
    Lee YL, Kim HJ, Lee MS, Kim JM, Han JS, Hong EK, Kwon MS, Lee MJ. Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model. Exp Anim 2003; 52: 3715.DOI: 10.1538/expanim.52.371
  • 11
    Menoli RC, Mantovani MS, Ribeiro LR, Speit G, Jordao BQ. Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells. Mutat Res 2001; 496: 513.
  • 12
    Delmanto RD, De Lima PL, Sugui MM, Da Eira AF, Salvadori DM, Speit G, Ribeiro LR. Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Mutat Res 2001; 496: 1521.
  • 13
    Martins de Oliveira J, Jordao BQ, Ribeiro LR, Ferreira da Eira A, Mantovani MS. Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro. Food Chem Toxicol 2002; 40: 177580.DOI: 10.1016/S0278-6915(02)00156-4
  • 14
    Barbisan LF, Scolastici C, Miyamoto M, Salvadori DM, Ribeiro LR, Da Eira AF, De Camargo JL. Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine. Genet Mol Res 2003; 2: 295308.
  • 15
    Guterrez ZR, Mantovani MS, Eira AF, Ribeiro LR, Jordao BQ. Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro. Toxicol Vitro 2004; 18: 3019.DOI: 10.1016/j.tiv.2003.09.003
  • 16
    Sorimachi K, Ikehara Y, Maezato G, Okubo A, Yamazaki S, Akimoto K, Niwa A. Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro. Biosci Biotechnol Biochem 2001; 65: 16457.DOI: 10.1271/bbb.65.1645
  • 17
    Talorete TP, Isoda H, Maekawa T. Agaricus blazei (class Basidiomycotina) aqueous extract enhances the expression of c-Jun protein in MCF7 cells. J Agric Food Chem 2002; 50: 51626.DOI: 10.1021/jf011566p
  • 18
    Kuo YC, Huang YL, Chen CC, Lin YS, Chuang KA, Tsai WJ. Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J Laboratory Clin Med 2002; 140: 17687.DOI: 10.1067/mlc.2002.126717
  • 19
    Shimizu S, Kitada H, Yokota H, Yamakawa J, Murayama T, Sugiyama K, Izumi H, Yamaguchi N. Activation of the alternative complement pathway by Agaricus blazei Murill. Phytomedicine 2002; 9: 53645.DOI: 10.1078/09447110260573047
  • 20
    Chen L, Shao HJ, Su YB. Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses. Int Immunopharmacol 2004; 4: 4039.
  • 21
    Mizuno M, Morimoto M, Minato K, Tsuchida H. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem 1998; 62: 4347.
  • 22
    Sorimachi K, Akimoto K, Ikehara Y, Inafuku K, Okubo A, Yamazaki S. Secretion of TNF-alpha, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro. Cell Struct Funct 2001; 26: 1038.DOI: 10.1247/csf.26.103
  • 23
    Nakajima A, Ishida T, Koga M, Takeuchi T, Mazda O, Takeuchi M. Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice. Int Immunopharmacol 2002; 2: 120511.DOI: 10.1016/S1567-5769(02)00056-5
  • 24
    Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 2003; 15: 396401.DOI: 10.1016/S0952-7915(03)00080-3
  • 25
    Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 24552.
  • 26
    Rescigno M, Granucci F, Citterio S, Foti M, Ricciardi-Castagnoli P. Coordinated events during bacteria-induced DC maturation. Immunol Today 1999; 20: 2003.DOI: 10.1016/S0167-5699(98)01427-3
  • 27
    Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999; 11: 3929.DOI: 10.1016/S0952-7915(99)80066-1
  • 28
    Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18: 767811.
  • 29
    Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity. J Exp Med 1996; 184: 74752.
  • 30
    Verhasselt V, Buelens C, Willems F, De Groote D, Haeffner-Cavaillon N, Goldman M. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J Immunol 1997; 158: 291925.
  • 31
    Trinchieri G. Interleukin-12. a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13: 25176.
  • 32
    Beutler B. TNF, immunity and inflammatory disease: lessons of the past decade. J Invest Med 1995; 43: 22735.
  • 33
    Mannel DN, Echtenacher B. TNF in the inflammatory response. Chem Immunol 2000; 74: 14161.
  • 34
    McIntyre KW, Shuster DJ, Gillooly KM et al. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol 1996; 26: 29338.
  • 35
    Parks E, Strieter RM, Lukacs NW, Gauldie J, Hitt M, Graham FL, Kunkel SL. Transient gene transfer of IL-12 regulates chemokine expression and disease severity in experimental arthritis. J Immunol 1998; 160: 46159.
  • 36
    Criscione LG, St Clair EW. Tumor necrosis factor-alpha antagonists for the treatment of rheumatic diseases. Curr Opin Rheumatol 2002; 14: 20411.
  • 37
    Shanahan JC, St Clair W. Tumor necrosis factor-alpha blockade: a novel therapy for rheumatic disease. Clin Immunol 2002; 103: 23142.DOI: 10.1006/clim.2002.5191
  • 38
    Roeder A, Kirschning CJ, Rupec RA, Schaller M, Korting HC. Toll-like receptors and innate antifungal responses. Trends Microbiol 2004; 12: 449.DOI: 10.1016/j.tim.2003.11.003
  • 39
    Cho HJ, Hayashi T, Datta SK, Takabayashi K, Van Uden JH, Horner A, Corr M, Raz E. IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J Immunol 2002; 168: 490713.
  • 40
    Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, Romani N, Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Meth 1999; 223: 7792.DOI: 10.1016/S0022-1759(98)00204-X
  • 41
    Du Breuil RM, Patel JM, Mendelow BV. Quantitation of beta-actin-specific mRNA transcripts using xeno-competitive PCR. PCR Meth Appl 1993; 3: 579.
  • 42
    Rieser C, Bock G, Klocker H, Bartsch G, Thurnher M. Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells. synergistic activation of interleukin 12 production. J Exp Med 1997; 186: 16038.DOI: 10.1084/jem.186.9.1603
  • 43
    Harizi H, Juzan M, Pitard V, Moreau JF, Gualde N. Cyclooxygenase-2-issued prostaglandin E2 enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J Immunol 2002; 168: 225563.
  • 44
    Xia Y, Vetvicka V, Yan J, Hanikyrova M, Mayadas T, Ross GD. The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells. J Immunol 1999; 162: 228190.
  • 45
    Marth T, Kelsall BL. Regulation of interleukin-12 by complement receptor 3 signaling. J Exp Med 1997; 185: 198795.DOI: 10.1084/jem.185.11.1987
  • 46
    Buentke E, Scheynius A. Dendritic cells and fungi. APMIS 2003; 111: 78996.
  • 47
    Netea MG, Van Der Graaf CA, Vonk AG, Verschueren I, Van Der Meer JW, Kullberg BJ.The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 2002 2002 April 30; 185: 14839. Epub.DOI: 10.1086/340511
  • 48
    Kataoka K, Muta T, Yamazaki S, Takeshige K. Activation of macrophages by linear (1[RIGHTWARDS ARROW]3)-beta-D-glucans. Impliations for the recognition of fungi by innate immunity. J Biol Chem 2002 2002 July 24; 277: 3682531. Epub.DOI: 10.1074/jbc.M206756200
  • 49
    Tada H, Nemoto E, Shimauchi H et al. Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner. Microbiol Immunol 2002; 46: 50312.
  • 50
    Jouault T, Ibata-Ombetta S, Takeuchi O, Trinel PA, Sacchetti P, Lefebvre P, Akira S, Poulain D.Candida albicans phospholipomannan is sensed through toll-like receptors. J Infect Dis 2003 2003 June 23; 188: 16572. Epub.DOI: 10.1086/375784
  • 51
    Kikuchi T, Ohno N, Ohno T. Maturation of dendritic cells induced by Candida beta-D-glucan. Int Immunopharmacol 2002; 2: 15038.DOI: 10.1016/S1567-5769(02)00084-X
  • 52
    Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 14573.DOI: 10.1146/annurev.iy.07.040189.001045
  • 53
    Kawakami K, Qureshi MH, Koguchi Y, Nakajima K, Saito A. Differential effect of Cryptococcus neoformans on the production of IL-12p40 and IL-10 by murine macrophages stimulated with lipopolysaccharide and gamma interferon. FEMS Microbiol Lett 1999; 175: 8794.DOI: 10.1016/S0378-1097(99)00172-X
  • 54
    Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, Trinchieri G, Griffin DE. Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996; 273: 22831.
  • 55
    De Diego J, Punzon C, Duarte M, Fresno M. Alteration of macrophage function by a Trypanosoma cruzi membrane mucin. J Immunol 1997; 159: 49839.
  • 56
    Kawakami K, Tohyama M, Teruya K, Kudeken N, Xie Q, Saito A. Contribution of interferon-gamma in protecting mice during pulmonary and disseminated infection with Cryptococcus neoformans. FEMS Immunol Med Microbiol 1996; 13: 12330.DOI: 10.1016/0928-8244(95)00093-3
  • 57
    Finke D, Brinckmann UG, Ter Meulen V, Liebert UG. Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis. J Virol 1995; 69: 546974.
  • 58
    Torrico F, Heremans H, Rivera MT, Van Marck E, Billiau A, Carlier Y. Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol 1991; 146: 362632.
  • 59
    Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 1997; 27: 313542.
  • 60
    Hedi H, Norbert G. Inhibition of IL-6, TNF-alpha, and cyclooxygenase-2 protein expression by prostaglandin E2-induced IL-10 in bone marrow-derived dendritic cells. Cell Immunol 2004; 228: 99109.DOI: 10.1016/j.cellimm.2004.04.003
  • 61
    Vassiliou E, Jing H, Ganea D. Prostaglandin E2 inhibits TNF production in murine bone marrow-derived dendritic cells. Cell Immunol 2003; 223: 12032.DOI: 10.1016/S0008-8749(03)00158-8
  • 62
    Scandella E, Men Y, Legler DF, Gillessen S, Prikler L, Ludewig B, Groettrup M. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood 2004; 103: 1595601.
  • 63
    Lee JJ, Takei M, Hori S et al. The role of PGE2 in the differentiation of dendritic cells: how do dendritic cells influence T-cell polarization and chemokine receptor expression? Stem Cells 2002; 20: 44859.DOI: 10.1634/stemcells.20-5-448
  • 64
    Morelli AE, Larregina AT, Shufesky WJ et al. Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood 2003; 101: 61120.
  • 65
    Yamada M, Oritani K, Kaisho T et al. Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells. Eur J Immunol 2004; 34: 22130.DOI: 10.1002/eji.200324026