• 1
    Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 78793.
  • 2
    Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12: 22757.
  • 3
    Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20: 197216.
  • 4
    Reis e Sousa C. Dendritic cells as sensors of infection. Immunity 2001; 14: 4958.
  • 5
    Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 24552.
  • 6
    Sallusto F, Lanzavecchia A. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J Exp Med 1999; 189: 61114.
  • 7
    Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 3947.
  • 8
    Poltorak A, He X, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 20858.
  • 9
    Brightbill HD, Libraty DH, Krutzik SR et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 1999; 285: 7326.
  • 10
    Hirschfeld M, Kirschning CJ, Schwandner R et al. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol 1999; 163: 23826.
  • 11
    Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999; 274: 174069.
  • 12
    Takeuchi O, Hoshino K, Kawai T et al. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 1999; 11: 44351.
  • 13
    Thoma-Uszynski S, Stenger S, Takeuchi O et al. Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001; 291: 15447.
  • 14
    Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge. recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999; 163: 15.
  • 15
    Hajjar AM, O'Mahony DS, Ozinsky A et al. Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J Immunol 2001; 166: 1519.
  • 16
    Ozinsky A, Underhill DM, Fontenot JD et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 1376671.
  • 17
    Takeuchi O, Kawai T, Muhlradt PF et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 2001; 13: 93340.
  • 18
    Hemmi H, Takeuchi O, Kawai T et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 7405.
  • 19
    Hayashi F, Smith KD, Ozinsky A et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001; 410: 1099103.
  • 20
    O'Neill LA. The role of MyD88-like adapters in Toll-like receptor signal transduction. Biochem Soc Trans 2003; 31: 6437.
  • 21
    Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. The human toll signaling pathway. divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 1998; 187: 2097101.
  • 22
    Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18: 767811.
  • 23
    Reis e Sousa Yap G, Schulz O et al. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology. Immunity 1999; 11: 63747.
  • 24
    Rescigno M, Granucci F, Ricciardi-Castagnoli P. Molecular events of bacterial-induced maturation of dendritic cells. J Clin Immunol 2000; 20: 1616.
  • 25
    Verhasselt V, Buelens C, Willems F, De Groote D, Haeffner-Cavaillon N, Goldman M. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J Immunol 1997; 158: 291925.
  • 26
    Edwards AD, Manickasingham SP, Sporri R et al. Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J Immunol 2002; 169: 365260.
  • 27
    Reis e Sousa C, Sher A , Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999; 11: 3929.
  • 28
    Dreher D, Kok M, Cochand L et al. Genetic background of attenuated Salmonella typhimurium has profound influence on infection and cytokine patterns in human dendritic cells. J Leukoc Biol 2001; 69: 5839.
  • 29
    Karlsson H, Larsson P, Wold AE, Rudin A. Pattern of cytokine responses to Gram-positive and Gram-negative commensal bacteria is profoundly changed when monocytes differentiate into dendritic cells. Infect Immun 2004; 72: 26718.
  • 30
    Smits HH, Van Beelen AJ, Hessle C et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 2004; 34: 137180.
  • 31
    Geijtenbeek TB, Van Vliet SJ, Koppel EA et al. Mycobacteria target DC-SIGN to suppress dendritic cell function. J Exp Med 2003; 197: 717.
  • 32
    Foster GR, Germain C, Jones M, Lechler RI, Lombardi G. Human T cells elicit IFN-alpha secretion from dendritic cells following cell to cell interactions. Eur J Immunol 2000; 30: 322835.
  • 33
    Cella M, Facchetti F, Lanzavecchia A, Colonna M. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat Immunol 2000; 1: 30510.
  • 34
    Diebold SS, Montoya M, Unger H et al. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 2003; 424: 3248.
  • 35
    Ito T, Amakawa R, Inaba M, Ikehara S, Inaba K, Fukuhara S. Differential regulation of human blood dendritic cell subsets by IFNs. J Immunol 2001; 166: 29619.
  • 36
    Montoya M, Schiavoni G, Mattei F et al. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 2002; 99: 326371.
  • 37
    Remoli ME, Giacomini E, Lutfalla G et al. Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis. J Immunol 2002; 169: 36674.
  • 38
    Muller U, Steinhoff U, Reis LF et al. Functional role of type I and type II interferons in antiviral defense. Science 1994; 264: 191821.
  • 39
    Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996; 184: 74752.
  • 40
    Koch F, Stanzl U, Jennewein P et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med 1996; 184: 7416.
  • 41
    Schulz O, Edwards AD, Schito M et al. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 2000; 13: 45362.
  • 42
    Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol 2000; 1: 199205.
  • 43
    Levings MK, Sangregorio R, Galbiati F, Squadrone S, De Waal MR, Roncarolo MG. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 2001; 166: 55309.
  • 44
    Rogge L, Barberis-Maino L, Biffi M et al. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 1997; 185: 82531.
  • 45
    Lanzavecchia A, Sallusto F. Regulation of T cell immunity by dendritic cells. Cell 2001; 106: 2636.
  • 46
    Andersen H, Birkelund S, Christiansen G, Freundt EA. Electrophoretic analysis of proteins from Mycoplasma hominis strains detected by SDS-PAGE, two-dimensional gel electrophoresis and immunoblotting. J Gen Microbiol 1987; 133: 18191.
  • 47
    Rappelli P, Addis MF, Carta F, Fiori PL. Mycoplasma hominis parasitism of Trichomonas vaginalis. Lancet 1998; 352: 1286.
  • 48
    Rappelli P, Carta F, Delogu G et al. Mycoplasma hominis and Trichomonas vaginalis symbiosis: multiplicity of infection and transmissibility of M. hominis to human cells. Arch Microbiol 2001; 175: 704.
  • 49
    Lanier LL, Warner NL. Paraformaldehyde fixation of hematopoietic cells for quantitative flow cytometry (FACS) analysis. J Immunol Meth 1981; 47: 2530.
  • 50
    Newman GR, Jasani B, Williams ED. The preservation of ultrastructure and antigenicity. J Microsc 1982; 127: RP5RP6.
  • 51
    Fedele G, Frasca L, Palazzo R, Ferrero E, Malavasi F, Ausiello CM. CD38 is expressed on human mature monocyte-derived dendritic cells and is functionally involved in CD83 expression and IL-12 induction. Eur J Immunol 2004; 34: 134250.
  • 52
    Gomez J, Borras FE, Singh R et al. Differential up-regulation of HLA-DM, invariant chain, and CD83 on myeloid and plasmacytoid dendritic cells from peripheral blood. Tissue Antigens 2004; 63: 14957.
  • 53
    Zhou LJ, Tedder TF. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol 1995; 154: 382135.
  • 54
    Giacomini E, Iona E, Ferroni L et al. Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response. J Immunol 2001; 166: 703341.
  • 55
    Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2: 67580.
  • 56
    Haller D, Blum S, Bode C, Hammes WP, Schiffrin EJ. Activation of human peripheral blood mononuclear cells by nonpathogenic bacteria in vitro. Evidence of NK cells as primary targets. Infect Immun 2000; 68: 7529.
  • 57
    Hirschfeld M, Weis JJ, Toshchakov V et al. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 2001; 69: 147782.
  • 58
    Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, Van Dyke T, Banchereau J. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 2001; 167: 506776.
  • 59
    Qi H, Denning TL, Soong L. Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles. Infect Immun 2003; 71: 333742.
  • 60
    Macatonia SE, Hosken NA, Litton M et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995; 154: 50719.
  • 61
    Elkord E, Williams PE, Kynaston H, Rowbottom AW. Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells. Immunology 2005; 114: 20412.
  • 62
    Jakobsen MA, Moller BK, Lillevang ST. Serum concentration of the growth medium markedly affects monocyte-derived dendritic cells' phenotype, cytokine production profile and capacities to stimulate in MLR. Scand J Immunol 2004; 60: 58491.
  • 63
    Koski GK, Lyakh LA, Rice NR. Rapid lipopolysaccharide-induced differentiation of CD14(+) monocytes into CD83(+) dendritic cells is modulated under serum-free conditions by exogenously added IFN-gamma and endogenously produced IL-10. Eur J Immunol 2001; 31: 377381.
  • 64
    Hessle C, Andersson B, Wold AE. Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while Gram-negative bacteria preferentially stimulate IL-10 production. Infect Immun 2000; 68: 35816.
  • 65
    Kariminia A, Kavoossy G, Khatami S, Zowghi E, Ardestani SK. Study of interleukin-10 and interleukin-12 productions in response to lipopolysaccharides extracted from two different Brucella strains. Comp Immunol Microbiol Infect Dis 2002; 25: 8593.
  • 66
    Xia CQ, Kao KJ. Suppression of IL-12 production through endogenously secreted IL-10 in activated dendritic cells: involvement of activation of extracellular signal-regulated protein kinase. Scand J Immunol 2003; 58: 2332.
  • 67
    Demangel C, Bertolino P, Britton WJ. Autocrine IL-10 impairs dendritic cell (DC) -derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Eur J Immunol 2002; 32: 9941002.
  • 68
    Zhou L, Nazarian AA, Smale ST. Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway. Mol Cell Biol 2004; 24: 238596.