Th9 and allergic disease
Article first published online: 21 MAY 2009
© 2009 Blackwell Publishing Ltd
Volume 127, Issue 4, pages 450–458, August 2009
How to Cite
Soroosh, P. and Doherty, T. A. (2009), Th9 and allergic disease. Immunology, 127: 450–458. doi: 10.1111/j.1365-2567.2009.03114.x
- Issue published online: 6 JUL 2009
- Article first published online: 21 MAY 2009
- Received 3 March 2009; revised 3 March 2009; accepted 31 March 2009.
- airway remodeling;
Helper CD4+ T-cell subsets have improved our understanding of adaptive immunity in humans and in animal models of disease. These include T helper type 1 (Th1), Th2 and the interleukin-17 (IL-17) -producing population ‘Th17’. Th2 cells have been described as orchestrating the immune response in allergic disease based on studies with patient samples and animal models. The cytokine IL-9 has largely been regarded as a Th2 cytokine that makes multifocal contributions to allergic disease. Recent data suggest that under certain conditions relevant to chronic disease (IL-4 and transforming growth factor-β), a distinct population of IL-9-producing ‘Th9’ helper T cells can exist. The contribution of Th9 cells in allergic disease is currently unknown, and this review will propose a model for how these cells may regulate chronic allergic inflammation.