Interleukin-9 as a T helper type 17 cytokine
Article first published online: 28 JUL 2010
© 2010 The Authors. Immunology © 2010 Blackwell Publishing Ltd
Volume 131, Issue 2, pages 169–173, October 2010
How to Cite
Nowak, E. C. and Noelle, R. J. (2010), Interleukin-9 as a T helper type 17 cytokine. Immunology, 131: 169–173. doi: 10.1111/j.1365-2567.2010.03332.x
- Issue published online: 2 SEP 2010
- Article first published online: 28 JUL 2010
- Received 15 June 2010; revised 21 June 2010; accepted 22 June 2010.
- CD4 T cell;
- T helper type 17;
- T helper type 9
The production of interleukin-9 (IL-9) by CD4 T cells has gathered renewed interest as the result of the observation that its expression is broader than originally thought. This includes the production of IL-9 by a recently characterized subset of CD4 helper T (Th) cells that are termed Th9 as well as production by additional T-cell subsets including Th17 cells. There is an incomplete understanding as to which IL-9-producing T-cell subsets develop under physiological conditions. We describe the conditions used to generate IL-9 in Th17 cells in vitro. We also summarize conditions where both IL-9 and IL-17 are found in vivo and propose that Th17 cells producing IL-9 may co-exist and interact with Th9 cells during conditions of autoimmunity, allergy and infection.