Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool
Article first published online: 25 AUG 2010
© 2010 The Authors. Immunology © 2010 Blackwell Publishing Ltd
Volume 131, Issue 3, pages 310–317, November 2010
How to Cite
Kim, C. and Williams, M. A. (2010), Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool. Immunology, 131: 310–317. doi: 10.1111/j.1365-2567.2010.03338.x
- Issue published online: 7 OCT 2010
- Article first published online: 25 AUG 2010
- Received 25 May 2010; revised 7 July 2010; accepted 12 July 2010.
- CD4/helper T cells;
- T-cell receptor;
- T cells;
The initiation of a T-cell response begins with the interaction of an individual T-cell clone with its cognate antigen presented by MHC. Although the strength of the T-cell receptor (TCR) –antigen–MHC (TCR-pMHC) interaction plays an important and obvious role in the recruitment of T cells into the immune response, evidence in recent years has suggested that the strength of this initial interaction can influence various other aspects of the fate of an individual T-cell clone and its daughter cells. In this review, we will describe differences in the way CD4+ and CD8+ T cells incorporate antigen-driven differentiation and survival signals during the response to acute infection. Furthermore, we will discuss increasing evidence that the quality and/or quantity of the initial TCR-pMHC interaction can drive the differentiation and long-term survival of T helper type 1 memory populations.