Transient modification within a pool of CD4 T cells in the maternal spleen
Article first published online: 7 OCT 2011
© 2011 The Authors. Immunology © 2011 Blackwell Publishing Ltd
Volume 134, Issue 3, pages 270–280, November 2011
How to Cite
Bonney, E. A., Shepard, M. T. and Bizargity, P. (2011), Transient modification within a pool of CD4 T cells in the maternal spleen. Immunology, 134: 270–280. doi: 10.1111/j.1365-2567.2011.03486.x
- Issue published online: 7 OCT 2011
- Article first published online: 7 OCT 2011
- Accepted manuscript online: 21 JUL 2011 10:40AM EST
- Received 16 January 2011; revised 22 May 2011; accepted 12 July 2011.
- lymphoid tissues;
- T cell receptor
Classic models suggest maternal tolerance is dependent on regulation of fetal antigen-specific T cell responses. We hypothesize that factors unique to a particular fetal antigen-specific T cell, rather than the state of pregnancy per se, are important determinants of T cell fate during pregnancy. To investigate the fate of fetal antigen-specific CD4 T cells in the systemic circulation, we examined spleen cells in a CD4 T cell receptor transgenic mouse specific for the male antigen H-Y. We observed a transient decrease in CD4+ Vβ6+ cell numbers and, due to transient internalization of CD4, an increase in CD4− Vβ6+ T cells. Antigen-specific in vitro responsiveness was not depressed by pregnancy. These data suggest that pregnancy supports fluidity in this particular CD4 T cell pool that may, in turn, help to meet competing requirements of maternal immune responsiveness and fetal tolerance.