Present address: Laboratory of Virology and Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells
Article first published online: 23 APR 2012
© 2012 The Author. Immunology © 2012 Blackwell Publishing Ltd
Volume 136, Issue 2, pages 133–138, June 2012
How to Cite
Shi, C. (2012), Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells. Immunology, 136: 133–138. doi: 10.1111/j.1365-2567.2012.03567.x
- Issue published online: 23 APR 2012
- Article first published online: 23 APR 2012
- Accepted manuscript online: 9 FEB 2012 05:51PM EST
- Received 21 November 2011; revised 8 January 2012; accepted 27 January 2012.
- cell trafficking;
- immune response;
- mesenchymal stem cells;
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as regenerative therapeutics. Cultured MSCs secrete various modulatory factors, which contribute to the immunosuppressive effects of transplanted MSCs as a therapy. Although the in vitro phenotype of MSCs has been well characterized, identification of MSCs in vivo is made difficult by the lack of specific markers. Current advances in murine MSC research provide valuable tools for studying the localization and function of MSCs in vivo. Recent findings suggest that MSCs exert diverse functions depending on tissue context and physiological conditions. This review focuses on bone marrow MSCs and their roles in haematopoiesis and immune responses.