XRC and MAI contributed equally to this article.
Syndecan-2 can promote clearance of T-cell receptor/CD3 from the cell surface
Article first published online: 2 OCT 2012
© 2012 The Authors. Immunology © 2012 Blackwell Publishing Ltd
Volume 137, Issue 3, pages 214–225, November 2012
How to Cite
Rovira-Clavé, X., Angulo-Ibáñez, M., Noguer, O., Espel, E. and Reina, M. (2012), Syndecan-2 can promote clearance of T-cell receptor/CD3 from the cell surface. Immunology, 137: 214–225. doi: 10.1111/j.1365-2567.2012.03626.x
- Issue published online: 2 OCT 2012
- Article first published online: 2 OCT 2012
- Accepted manuscript online: 10 AUG 2012 10:57AM EST
- Manuscript Accepted: 13 JUL 2012
- Manuscript Revised: 10 JUL 2012
- Manuscript Received: 1 APR 2012
- Spanish Ministry of Education and Science. Grant Number: SAF2004-05481
Figure S1. Expression of SDC2 in resting and activated primary CD4+ T cells.
Figure S2. Expression of Fas, CD69, MHC class I, CD4 and transferrin receptor (TfR) in sdc2-transfected and control untransfected Jurkat cells as analysed by flow cytometry.
Figure S3. CD3-stimulation of CD4 T cells triggers T-cell receptor ζ degradation.
Figure S4. Intracellular location of internalized CD3ε in CD4 T lymphocytes.
Figure S5. SDC2-mediated T-cell receptor/CD3 down-regulation is independent of Arf6 activity.
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