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Figure S1. Expression of SDC2 in resting and activated primary CD4+ T cells.

Figure S2. Expression of Fas, CD69, MHC class I, CD4 and transferrin receptor (TfR) in sdc2-transfected and control untransfected Jurkat cells as analysed by flow cytometry.

Figure S3. CD3-stimulation of CD4 T cells triggers T-cell receptor ζ degradation.

Figure S4. Intracellular location of internalized CD3ε in CD4 T lymphocytes.

Figure S5. SDC2-mediated T-cell receptor/CD3 down-regulation is independent of Arf6 activity.

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