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The PKA-CREB system encoded by the honeybee genome
Article first published online: 27 OCT 2006
Insect Molecular Biology
Volume 15, Issue 5, pages 551–561, October 2006
How to Cite
Eisenhardt, D., Kühn, C. and Leboulle, G. (2006), The PKA-CREB system encoded by the honeybee genome. Insect Molecular Biology, 15: 551–561. doi: 10.1111/j.1365-2583.2006.00668.x
- Issue published online: 27 OCT 2006
- Article first published online: 27 OCT 2006
- Received 16 March 2006; accepted after revision May 2006.
- honeybee genome;
- destabilizing elements
The cAMP-dependent kinase (PKA) plays a crucial part in long-term memory formation in the honeybee (Apis mellifera). One of the putative substrates of the PKA activity is the cAMP response element binding protein (CREB), a transcription factor in the bZIP protein family. We searched the honeybee genome to characterize genes from the CREB/CREM and the PKA families. We identified two genes that encode regulatory subunits and three genes encode catalytic subunits of PKA. Eight genes code for bZIP proteins, but only one gene was found that encodes a member of the CREB/CREM family. The phylogenetic relationship of these genes was analysed with their Drosophila and human counterparts.