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A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
Article first published online: 27 OCT 2006
Insect Molecular Biology
Volume 15, Issue 5, pages 615–636, October 2006
How to Cite
Claudianos, C., Ranson, H., Johnson, R. M., Biswas, S., Schuler, M. A., Berenbaum, M. R., Feyereisen, R. and Oakeshott, J. G. (2006), A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee. Insect Molecular Biology, 15: 615–636. doi: 10.1111/j.1365-2583.2006.00672.x
- Issue published online: 27 OCT 2006
- Article first published online: 27 OCT 2006
- Received 19 April 2006; accepted after revision 30 May 2006.
- cytochrome P450 monooxygenase;
- insecticide resistance
The honeybee genome has substantially fewer protein coding genes (≈ 11 000 genes) than Drosophila melanogaster (≈ 13 500) and Anopheles gambiae (≈ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.