These authors contributed equally to this work.
Molecular characterization of the Aedes aegypti odorant receptor gene family
Article first published online: 17 JUL 2007
Insect Molecular Biology
Volume 16, Issue 5, pages 525–537, October 2007
How to Cite
Bohbot, J., Pitts, R. J., Kwon, H.-W., Rützler, M., Robertson, H. M. and Zwiebel, L. J. (2007), Molecular characterization of the Aedes aegypti odorant receptor gene family. Insect Molecular Biology, 16: 525–537. doi: 10.1111/j.1365-2583.2007.00748.x
- Issue published online: 17 JUL 2007
- Article first published online: 17 JUL 2007
- Received 22 March 2007; accepted after revision 10 May 2007.
- odourant receptor;
- Aedes aegypti;
- Anopheles gambiae
The olfactory-driven blood-feeding behaviour of female Aedes aegypti mosquitoes is the primary transmission mechanism by which the arboviruses causing dengue and yellow fevers affect over 40 million individuals worldwide. Bioinformatics analysis has been used to identify 131 putative odourant receptors from the A. aegypti genome that are likely to function in chemosensory perception in this mosquito. Comparison with the Anopheles gambiae olfactory subgenome demonstrates significant divergence of the odourant receptors that reflects a high degree of evolutionary activity potentially resulting from their critical roles during the mosquito life cycle. Expression analyses in the larval and adult olfactory chemosensory organs reveal that the ratio of odourant receptors to antennal glomeruli is not necessarily one to one in mosquitoes.