The Aedes aegypti genome: a comparative perspective

Authors

  • R. M. Waterhouse,

    1. Imperial College London, South Kensington Campus, London, UK;
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  • S. Wyder,

    1. Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland; and
    2. Swiss Institute of Bioinformatics, Geneva, Switzerland
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  • E. M. Zdobnov

    1. Imperial College London, South Kensington Campus, London, UK;
    2. Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland; and
    3. Swiss Institute of Bioinformatics, Geneva, Switzerland
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Evgeny M. Zdobnov, Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel-Servet, 1211 Geneva, Switzerland. Tel.: +41 22 379 59 73; fax: +41 22 379 57 06; e-mail: zdobnov@medecine.unige.ch

Abstract

The sequencing of the second mosquito genome, Aedes aegypti, in addition to Anopheles gambiae, is a major milestone that will drive molecular-level and genome-wide high-throughput studies of not only these but also other mosquito vectors of human pathogens. Here we overview the ancestry of the mosquito genes, list the major expansions of gene families that may relate to species adaptation processes, as exemplified by CYP9 cytochrome P450 genes, and discuss the conservation of chromosomal gene arrangements among the two mosquitoes and fruit fly. Many more invertebrate genomes are expected to be sequenced in the near future, including additional vectors of human pathogens (see http://www.vectorbase.org), and further comparative analyses will become increasingly refined and informative, hopefully improving our understanding of the genetic basis of phenotypical differences among these species, their vectorial capacity, and ultimately leading to the development of novel disease control strategies.

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