The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes
Article first published online: 14 MAR 2008
© 2008 The Authors
Insect Molecular Biology
Volume 17, Issue 2, pages 103–112, April 2008
How to Cite
Meredith, J. M., Hurd, H., Lehane, M. J. and Eggleston, P. (2008), The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes. Insect Molecular Biology, 17: 103–112. doi: 10.1111/j.1365-2583.2008.00786.x
- Issue published online: 14 MAR 2008
- Article first published online: 14 MAR 2008
- Received 21 August 2007; accepted after revision 21 November 2007.
- defensin genes;
- Anopheles gambiae;
- antimicrobial peptide
cDNAs of Anopheles gambiae Defensin 2 (AgDef2), Defensin 3 (AgDef3) and Defensin 4 (AgDef4), identified in the genome sequence, have been characterized and their expression profiles investigated. In contrast to both typical defensins and insect antimicrobial peptides generally, the newly identified defensins were not upregulated with acute-phase kinetics following immune challenge in insects or cell culture. However, mRNA abundance of AgDef2, AgDef3 and AgDef4 increased significantly during the larval stages. Promoter analysis of all three genes failed to identify putative immune response elements previously identified in other mosquito defensin genes. As previous studies failed to identify these larval-specific defensins, it seems likely that further antimicrobial peptide genes with nontypical expression profiles will be identified as more genome sequences become available.