Silkmoth chorion gene regulation revisited: promoter architecture as a key player
Article first published online: 7 DEC 2009
© 2009 The Authors. Journal compilation © 2009 The Royal Entomological Society
Insect Molecular Biology
Volume 19, Issue 2, pages 141–151, April 2010
How to Cite
Lecanidou, R. and Papantonis, A. (2010), Silkmoth chorion gene regulation revisited: promoter architecture as a key player. Insect Molecular Biology, 19: 141–151. doi: 10.1111/j.1365-2583.2009.00969.x
- Issue published online: 3 MAR 2010
- Article first published online: 7 DEC 2009
- First published online 7 December 2009.
- Bombyx mori;
- chorion genes;
- promoter architecture;
- transcription factors
Regulation of silkmoth chorion genes has long been used as a model system for studying differential gene expression. The large numbers of genes, their overlapping expression patterns and the overall complexity of the system hinted towards an elaborate mechanism for transcriptional control. Recent studies, however, offer evidence of a molecular pathway governed by the interplay between two general transcription factors, CCAAT enhancer binding proteins (C/EBP) and GATA, an architectural protein, high mobility group A and a chromatin remodeller, chromo-helicase/ATPase-DNA binding protein 1. In this review we present a parsimonious model that adequately describes regulation of transcription across all temporally regulated chorion genes, and propose a role for promoter architecture.