A review for the EAA International Symposium on ‘Genetics of male infertility: from research to clinic’, Florence, Italy.
The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis*
Article first published online: 3 DEC 2004
International Journal of Andrology
Volume 27, Issue 6, pages 328–334, December 2004
How to Cite
Elliott, D. J. (2004), The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis. International Journal of Andrology, 27: 328–334. doi: 10.1111/j.1365-2605.2004.00496.x
- Issue published online: 3 DEC 2004
- Article first published online: 3 DEC 2004
- Received 18 November 2003; revised 28 April 2004; accepted 10 May 2004
- gene expression;
- signal transduction
Investigations into the RBM gene family are uncovering networks of protein interactions which regulate RNA processing, and which might operate downstream of signal transduction pathways. Similar pathways likely operate in germ cells and somatic cells, with RBMY, hnRNPGT and T-STAR proteins providing germ cell-specific components. These pathways may be important for normal germ cell development, and might be compromised in men with Y chromosome deletions affecting RBMY gene expression. The STAR proteins have multiple functions in pre-mRNA splicing, signalling and cell cycle control. These processes might have to be very finely regulated during germ cell development, which involves both two sequential meiotic divisions (meiosis I and II) as well as mitotic (spermatogonial) cell divisions, and which is controlled by paracrine signalling within the testis from Sertoli cells.