Chronic inflammation: a failure of resolution?
Article first published online: 8 DEC 2006
International Journal of Experimental Pathology
Volume 88, Issue 2, pages 85–94, April 2007
How to Cite
Lawrence, T. and Gilroy, D. W. (2007), Chronic inflammation: a failure of resolution?. International Journal of Experimental Pathology, 88: 85–94. doi: 10.1111/j.1365-2613.2006.00507.x
- Issue published online: 8 DEC 2006
- Article first published online: 8 DEC 2006
- Received for publication: 13 August 2006 Accepted for publication: 7 September 2006
- acute inflammationn;
- chronic inflammation;
Inflammation has evolved as a protective response to insult or injury, it's a primordial response that eliminates or neutralises foreign organisms or material, the resolution of inflammation encompasses the endogenous anti-inflammatory mechanisms that protect us against excessive tissue injury and promote the restoration of tissue structure and function. In fact, our well being and survival depends upon its efficiency and carefully-balanced control. In general, the innate inflammatory response initiates within minutes and, if all is well, resolves within hours. In contrast, chronic inflammation persists for weeks, months or even years. Here, we are going to discuss the key endogenous checkpoints necessary for mounting an effective yet limited inflammatory response and the crucial biochemical pathways necessary to prevent its persistence.