Oxidative stress in obstructive nephropathy


Prof. Dr. R. Goldschmeding
Department of Pathology
University Medical Center
Utrecht Heidelberglaan 100
3584 CX Utrecht
The Netherlands
Tel.: +31 88 755 6559
Fax: +31 30 2544990
E-mail: r.goldschmeding@umcutrecht.nl


Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.