Antihypertensive Activities of Peptides Derived from Porcine Skeletal Muscle Myosin in Spontaneously Hypertensive Rats


  • This work was supported in part by a Grant-in-Aid for Scientific Research (Nr 11660272) from the Ministry of Education, Science and Culture of Japan, and the School of Veterinary Medicine and Animal Sciences, Kitasato Univ. Portions of this paper were presented at the 46th International Congress of Meat Science and Technology held on 27 August to 1 September 2000, Buenos Aires, Argentina.


ABSTRACT: Antihypertensive activities derived from porcine skeletal muscle proteins were investigated. Thermolysin hydrolysates of porcine muscle water-insoluble proteins demonstrated antihypertensive activities in spontaneously hypertensive rats when administrated in single oral doses. Hydrolysates of porcine myosin and peptides (Met-Asn-Pro-Pro-Lys, Ile-Thr-Thr-Asn-Pro, Met-Asn-Pro, Pro-Pro-Lys) with parts of the sequence of myosin showed antihypertensive activities. This is the first report of antihypertensive activities of peptides derived from muscle proteins of domestic animals. The hydrolysates of porcine muscle protein and their corresponding bioactive peptides might be utilized for physiologically functional foods.