This work was supported in part by a Grant-in-Aid for Scientific Research (Nr 11660272) from the Ministry of Education, Science and Culture of Japan, and the School of Veterinary Medicine and Animal Sciences, Kitasato Univ. Portions of this paper were presented at the 46th International Congress of Meat Science and Technology held on 27 August to 1 September 2000, Buenos Aires, Argentina.
Antihypertensive Activities of Peptides Derived from Porcine Skeletal Muscle Myosin in Spontaneously Hypertensive Rats
Article first published online: 20 JUL 2006
Journal of Food Science
Volume 67, Issue 1, pages 434–437, January 2002
How to Cite
Nakashima, Y., Arihara, K., Sasaki, A., Mio, H., Ishikawa, S. and Itoh, M. (2002), Antihypertensive Activities of Peptides Derived from Porcine Skeletal Muscle Myosin in Spontaneously Hypertensive Rats. Journal of Food Science, 67: 434–437. doi: 10.1111/j.1365-2621.2002.tb11424.x
- Issue published online: 20 JUL 2006
- Article first published online: 20 JUL 2006
- MS 20001561 Submitted 11/12/00, Accepted 4/11/01, Received 5/3/01
- antihypertensive activity;
- porcine skeletal muscle;
- spontaneously hypertensive rat
ABSTRACT: Antihypertensive activities derived from porcine skeletal muscle proteins were investigated. Thermolysin hydrolysates of porcine muscle water-insoluble proteins demonstrated antihypertensive activities in spontaneously hypertensive rats when administrated in single oral doses. Hydrolysates of porcine myosin and peptides (Met-Asn-Pro-Pro-Lys, Ile-Thr-Thr-Asn-Pro, Met-Asn-Pro, Pro-Pro-Lys) with parts of the sequence of myosin showed antihypertensive activities. This is the first report of antihypertensive activities of peptides derived from muscle proteins of domestic animals. The hydrolysates of porcine muscle protein and their corresponding bioactive peptides might be utilized for physiologically functional foods.