Antidiabetic activity of flavone from Ipomoea Batatas leaf in non-insulin dependent diabetic rats

  1. Rui Zhao1,
  2. Qingwang Li1,2,*,
  3. Ling Long2,
  4. Jian Li1,
  5. Runjun Yang2,
  6. Dawei Gao1

Article first published online: 26 OCT 2006

DOI: 10.1111/j.1365-2621.2006.01215.x

Issue

International Journal of Food Science & Technology

International Journal of Food Science & Technology

Volume 42, Issue 1, pages 80–85, January 2007

Additional Information

How to Cite

Zhao, R., Li, Q., Long, L., Li, J., Yang, R. and Gao, D. (2007), Antidiabetic activity of flavone from Ipomoea Batatas leaf in non-insulin dependent diabetic rats. International Journal of Food Science & Technology, 42: 80–85. doi: 10.1111/j.1365-2621.2006.01215.x

Author Information

  1. 1

     Department of Biological Engineering, Yanshan University, 438 Hebei Street, Qinhuangdao 066004, China

  2. 2

     School of Animal Science, Northwest A&F University, 22 Xinong Street, Yangling 712100, China

* *Correspondent and present address: Department of Biological Engineering, School of Environment and Chemistry Engineering, Yanshan University, 438 Hebei Street, Qinhuangdao 066004, China. Fax: +86 0335 8074662; e-mail: qingwangli@hotmail.com

Publication History

  1. Issue published online: 31 OCT 2006
  2. Article first published online: 26 OCT 2006
  3. (Received 27 July 2005; Accepted in revised form 12 January 2006)

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Keywords:

  • Blood glucose;
  • flavone;
  • free radicals;
  • Ipomoea batatas;
  • non-insulin dependent diabetes mellitus;
  • serum lipid profiles

Summary

The effects of flavone extracted from Ipomoea batatas leaf (FIBL) on body weight, blood glucose, serum lipid profiles, serum insulin and free radicals in rats with non-insulin dependent diabetes mellitus (NIDDM) were studied. FIBL treatment (25, 50, 100 mg kg−1) for 2 weeks resulted in a significant decrease in the concentration of plasma triglyceride (TG), plasma cholesterol (TC) and weight in NIDDM rats. Furthermore, FIBL markedly decreased fasting plasma insulin level, blood glucose (FBG) level, low-density lipoprotein cholesterol (LDL-C), and malondialdehyde (MDA) levels and significantly increased the Insulin Sensitive Index (ISI) and superoxide dismutase (SOD) level in NIDDM rats. In addition, flavone extracted from I. batatas leaf did not show any physical or behavioural signs of toxicity. More significantly, our data demonstrate the FIBL at the dose of 50 mg kg−1 body weight exhibited the optimal effect. The above results suggest that flavone extracted from I. batatas leaf could control blood glucose and modulate the metabolism of glucose and blood lipid, and decrease outputs of lipid peroxidation and scavenge the free radicals in non-insulin dependent diabetic rats.

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