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Keywords:

  • Diheptanoin;
  • medium chain triacylglycerols;
  • toxicological analysis;
  • triheptanoin

Summary

The aim of this study was to synthesise glycerol esters from heptanoic acid and to evaluate the toxicity of their chronic consumption in rats. The synthesised product (64% triheptanoin, 34% diheptanoin and 2% monoheptanoin) was called experimental oil. Newly weaned male Wistar rats (n = 3 × 10) were fed with control diet AIN-93, control with 30% substitution of soybean oil with experimental oil (TAGC7 30%) or control with substitution of 50% (TAGC7 50%), for 9 months. The experimental oil did not affect the growth, lipid digestibility or hepatic and renal function, and the lipid profile serum analysis. Additionally, it exhibited a hepato-protector effect in group TAGC7 50%. In conclusion, the chronic consumption of di- and triheptanoin was not toxic in rats, suggesting that they may be used in the treatment of disorders in which more easily digestible lipids are required.