Appendix S1. Detailed structure of the set of models used in the multi-event analysis.

Appendix S2. Single-state analyses.

Fig. S1. Results of Western Blot analyses to assess the relationship between the immunological status of a serum sample and its value of optical density obtained from an ELISA analysis.

Table S1. Structure of multi-event models that were used in the analysis.

Table S2. Detailed results of the model selection procedure of the multi-event analysis.

Table S3. Estimates of all identifiable parameters of the best model.

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