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Appendix S1. Additional raw data and full ANOVA tables for the analysis of certain performance components from the fitness experiment, data from the bioassays of caged populations in the selection experiment, and sensitivity analyses for spray threshold, and virus decay rates in the simulation modelling. Table S1. Additional performance parameters for Karak resistant, Karak X Lab UK heterozygotes and Lab UK susceptible insects in the fitness experiment. Table S2. ANOVA table for the fitness experiment. Table S3. ANOVA table for fecundity of Karak resistant, Karak X Lab UK heterozygotes and Lab UK susceptible insects in the fitness experiment. Table S4. Analysis of deviance for proportional egg fertility. Table S5. Maximum likelihood mixed model ANOVAs for the selection experiment. Fig. S1. Raw data from the selection experiment: generation 2. Fig. S2. Raw data from the selection experiment: generation 4. Fig. S3. Raw data from the selection experiment: generation 6. Fig. S4. The evolution of resistance to Bt in a simulated insect population controlled with the ?rotation+ epizootic? strategy and a second pathogen of varying persistence and pathogenicity. Fig. S5. Sensitivity analysis for the consequences of varying spray threshold and virus decay rate in the ?rotation+epizootic? strategy. Fig. S6. Sensitivity analysis for the consequences of varying spray threshold and virus decay rate in the ?rotation+epizootic? strategy.

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