• 1
    Steiner TJ, Voelker M (2009) Gastrointestinal tolerability of aspirin and the choice of over-the-counter analgesia for short-lasting acute pain. Journal of Clinical Pharmacy and Therapeutics, 34, 177186.
  • 2
    Loke YK (2009) Aspirin or paracetamol – what’s good for you? Journal of Clinical Pharmacy and Therapeutics, 34, 247248.
  • 3
    Raffa R (2006) Pharmacological aspects of successful long-term analgesia. Clinical Rheumatology, 25(Suppl. 1), S9S15.
  • 4
    D’Mello R, Dickenson AH (2008) Spinal cord mechanisms of pain. British Journal of Anaesthesiology, 101, 816.
  • 5
    Kadiev E, Patel V, Rad P et al. (2008) Role of pharmacogenetics in variable response to drugs: focus on opioids. Expert Opinion in Drug Metabolism and Toxicology, 4, 7791.
  • 6
    Sneader W (2005) Drug discovery a history. West Sussex: John Wiley & Sons Ltd. 438439.
  • 7
    Spooner JB, Harvey JG (1976) The history and usage of paracetamol. The Journal of International Medical Research, 4, 16.
  • 8
    Clissold SP (1986) Paracetamol and phenacetin. Drugs, 32(Suppl. 4), 4659.
  • 9
    Prescott LF (2000) Paracetamol: past, present, and future. American Journal of Therapeutics, 7, 143147.
  • 10
    Brodie BB, Axelrod J (1948) The fate of acetanilide in man. The Journal of Pharmacology and Experimental Therapeutics, 94, 2938.
  • 11
    Brodie BB, Axelrod J (1949) The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material. The Journal of Pharmacology and Experimental Therapeutics, 97, 5867.
  • 12
    Black M (1984) Acetaminophen hepatotoxicity. Annual Review of Medicine, 35, 577593.
  • 13
    Chou R, Huffman LH, American Pain S, American College of P (2007) Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of Internal Medicine, 147, 505514.
  • 14
    Zhang W, Doherty M, Leeb BF et al. (2007) EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Annals of The Rheumatic Diseases, 66, 377388.
  • 15
    HardmanJG, LimbirdLE, GilmanAG, eds (2001) Goodman and Gilman’s the pharmacological basis of therapeutics. 10th edn, New York: McGraw-Hill.
  • 16
    Lambrecht FY, Durkan K, Yildirim Y, Acar C (2006) Labeling of acetaminophen with I-131 and biodistribution in rats. Chemical and Pharmaceutical Bulletin (Tokyo), 54, 245247.
  • 17
    Fukuda M, Kitaichi K, Abe F et al. (2005) Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice. Journal of Pharmacological Sciences, 97, 525532.
  • 18
    Anderson BJ, Holford NH, Woollard GA, Chan PL (1998) Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children. British Journal of Clinical Pharmacology, 46, 237243.
  • 19
    Van Der Marel CD, Anderson BJ, Pluim MA, De Jong TH, Gonzalez A, Tibboel D (2003) Acetaminophen in cerebrospinal fluid in children. European Journal of Clinical Pharmacology, 59, 297302.
  • 20
    Gibb IA, Anderson BJ (2008) Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration. Archives of Disease in Childhood, 93, 241247.
  • 21
    Sachs CJ (2005) Oral analgesics for acute nonspecific pain. American Family Physician, 71, 913918.
  • 22
    Dalton JD Jr, Schweinle JE (2006) Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. Annals of Emergency Medicine, 48, 615623.
  • 23
    Sinatra RS, Jahr JS, Reynolds LW, Viscusi ER, Groudine SB, Payen-Champenois C (2005) Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology, 102, 822831.
  • 24
    Loeser JD, Treede RD (2008) The Kyoto protocol of IASP Basic Pain Terminology. Pain, 137, 473477.
  • 25
    Gelgor L, Cartmell S, Mitchell D (1992) Intracerebroventricular micro-injections of non-steroidal anti-inflammatory drugs abolish reperfusion hyperalgesia in the rat’s tail. Pain, 50, 323329.
  • 26
    Bianchi M, Panerai AE (1996) The dose-related effects of paracetamol on hyperalgesia and nociception in the rat. British Journal of Pharmacology, 117, 130132.
  • 27
    Bianchi M, Panerai AE (1997) Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol. Neuroscience Letters, 237, 8992.
  • 28
    Sandrini M, Romualdi P, Capobianco A, Vitale G, Morelli G, Pini LA, Candeletti S (2001) The effect of paracetamol on nociception and dynorphin A levels in the rat brain. Neuropeptides, 35, 110116.
  • 29
    Choi SS, Lee JK, Suh HW (2001) Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models. Brain Research, 921, 233239.
  • 30
    Bonnefont J, Alloui A, Chapuy E, Clottes E, Eschalier A (2003) Orally administered paracetamol does not act locally in the rat formalin test: evidence for a supraspinal, serotonin-dependent antinociceptive mechanism. Anesthesiology, 99, 976981.
  • 31
    Nagakura Y, Okada M, Kohara A et al. (2003) Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics. The Journal of Pharmacology and Experimental Therapeutics, 306, 490497.
  • 32
    Koppert W, Wehrfritz A, Korber N, Sittl R, Albrecht S, Schuttler J, Schmelz M (2004) The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain, 108, 148153.
  • 33
    Bolcskei K, Horvath D, Szolcsanyi J, Petho G (2007) Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model. European Journal of Pharmacology, 564, 8087.
  • 34
    Bianchi M, Martucci C, Ferrario P, Franchi S, Sacerdote P (2007) Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs. Anesthesia and Analgesia, 104, 949954.
  • 35
    Crawley B, Saito O, Malkmus S, Fitzsimmons B, Hua XY, Yaksh TL (2008) Acetaminophen prevents hyperalgesia in central pain cascade. Neuroscience Letters, 442, 5053.
  • 36
    Rezende RM, Franca DS, Menezes GB, Dos Reis WG, Bakhle YS, Francischi JN (2008) Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. British Journal of Pharmacology, 153, 760768.
  • 37
    Luccarini P, Childeric A, Gaydier A-M, Voisin D, Dallel R (2006) The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception. The Journal of Pain, 7, 908914.
  • 38
    Matsunaga A, Kawamoto M, Shiraishi S, Yasuda T, Kajiyama S, Kurita S, Yuge O (2007) Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats. European Journal of Pharmacology, 554, 1217.
  • 39
    Cui JG, Zhang X, Zhao YH, Chen C, Bazan N (2006) Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain. Biochemical and Biophysical Research Communications, 350, 358363.
  • 40
    Dani Ml, Guindon Je, Lambert C, Beaulieu P (2007) The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors. European Journal of Pharmacology, 573, 214215.
  • 41
    Saito O, Aoe T, Yamamoto T (2005) Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain. Journal of Anesthesia, 19, 218224.
  • 42
    Lynch JJ, Wade CL, Zhong CM, Mikusa JP, Honore P (2004) Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model. Pain, 110, 5663.
  • 43
    Leinisch E, Evers S, Kaempfe N et al. (2005) Evaluation of the efficacy of intravenous acetaminophen in the treatment of acute migraine attacks: a double-blind, placebo-controlled parallel group multicenter study. Pain, 117, 396400.
  • 44
    Lipton RB, Baggish JS, Stewart WF, Codispoti JR, Fu M (2000) Efficacy and safety of acetaminophen in the treatment of migraine: results of a randomized, double-blind, placebo-controlled, population-based study. Archives of Internal Medicine, 160, 34863492.
  • 45
    Akin M, Price W, Rodriguez G Jr, Erasala G, Hurley G, Smith RP (2004) Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea. The Journal of Reproductive Medicine, 49, 739745.
  • 46
    Clark WG, Cumby HR (1976) Antagonism by antipyretics of the hyperthermic effect of a prostaglandin precursor, sodium arachidonate, in the cat. The Journal of Physiology, 257, 581595.
  • 47
    Li S, Dou W, Tang Y, Goorha S, Ballou LR, Blatteis CM (2008) Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant Prostaglandins & Other Lipid Mediators, 85, 8999.
  • 48
    Crawford IL, Kennedy JI, Lipton JM, Ojeda SR (1979) Effects of central administation of probenecid on fevers produced by leukocytic pyrogen and PGE2 in the rabbit. The Journal of Physiology, 287, 519533.
  • 49
    Huang W-T, Wang J-J, Lin M-T (2004) Antipyretic effect of acetaminophen by inhibition of glutamate release after staphylococcal enterotoxin A fever in rabbits. Neuroscience Letters, 355, 3336.
  • 50
    Devi BP, Boominathan R, Mandal SC (2003) Evaluation of antipyretic potential of Cleome viscosa Linn(Capparidaceae) extract in rats. Journal of Ethnopharmacology, 87, 1113.
  • 51
    Tomazetti J, Avila DS, Ferreira AP et al. (2005) Baker yeast-induced fever in young rats: characterization and validation of an animal model for antipyretics screening. Journal of Neuroscience Methods, 147, 2935.
  • 52
    Massey TE, Walker RM, McElligott TF, Racz WJ (1982) Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. Toxicology, 25, 187200.
  • 53
    Ayoub SS, Botting RM, Goorha S, Colville-Nash PR, Willoughby DA, Ballou LR (2004) Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein. Proceedings of the National Academy of Sciences of the United States of America, 101, 1116511169.
  • 54
    Stevens T, Fitzsimmons L (1995) Effect of a standardized rewarming protocol and acetaminophen on core temperature after coronary artery bypass. American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses, 4, 189197.
  • 55
    Kasner SE, Wein T, Piriyawat P et al. (2002) Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial Stroke. A Journal of Cerebral Circulation, 33, 130134.
  • 56
    Dippel DW, Van Breda EJ, Van Der Worp HB, Van Gemert HM, Kappelle LJ, Algra A, Koudstaal PJ (2003) Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. Neurology, 61, 677679.
  • 57
    Mellergard P (1992). Changes in human intracerebral temperature in response to different methods of brain cooling. Neurosurgery, 31, 671677; discussion 677.
  • 58
    Honore P, Buritova J, Besson JM (1995) Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation. Pain, 63, 365375.
  • 59
    Abbadie C, Besson JM (1994) Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and Fos-like immunoreactivity in rat lumbar spinal cord. Pain, 57, 4554.
  • 60
    Mamuk S, Melli M (2007) Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats. European Journal of Pharmacology, 561, 220225.
  • 61
    Lee Y-S, Kim H, Brahim JS, Rowan J, Lee G, Dionne RA (2007) Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain, 129, 279286.
  • 62
    Al-Swayeh OA, Futter LE, Clifford RH, Moore PK (2000) Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity. British Journal of Pharmacology, 130, 14531456.
  • 63
    Alloui A, Chassaing C, Schmidt J, Ardid D, Dubray C, Cloarec A, Eschalier A (2002) Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats. European Journal of Pharmacology, 443, 7177.
  • 64
    Brandt KD, Mazzuca SA, Buckwalter KA (2006) Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees. Rheumatology (Oxford, England), 45, 13891394.
  • 65
    Case JP, Baliunas AJ, Block JA (2003) Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Archives of Internal Medicine, 163, 169178.
  • 66
    Lages B, Weiss HJ (1989) Inhibition of human platelet function in vitro and ex vivo by acetaminophen. Thrombosis Research, 53, 603613.
  • 67
    Munsterhjelm E, Munsterhjelm NM, Niemi TT, Ylikorkala O, Neuvonen PJ, Rosenberg PH (2005) Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers. Anesthesiology, 103, 712717.
  • 68
    Munsterhjelm E, Niemi TT, Syrjala MT, Ylikorkala O, Rosenberg PH (2003) Propacetamol augments inhibition of platelet function by diclofenac in volunteers. British Journal of Anaesthesia, 91, 357362.
  • 69
    Munsterhjelm E, Niemi TT, Ylikorkala O, Silvanto M, Rosenberg PH (2005) Characterization of inhibition of platelet function by paracetamol and its interaction with diclofenac in vitro. Acta Anaesthesiologica Scandinavica, 49, 840846.
  • 70
    Niemi TT, Backman JT, Syrjala MT, Viinikka LU, Rosenberg PH (2000) Platelet dysfunction after intravenous ketorolac or propacetamol. Acta Anaesthesiologica Scandinavica, 44, 6974.
  • 71
    Sciulli MG, Seta F, Tacconelli S, Capone ML, Ricciotti E, Pistritto G, Patrignani P (2003) Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells. British Journal of Pharmacology, 138, 634641.
  • 72
    Rao GH, Reddy KR, White JG (1982) Effect of acetaminophen and salicylate on aspirin-induced inhibition of human platelet cyclo-oxygenase. Prostaglandins, Leukotrienes, and Medicine, 9, 109115.
  • 73
    Scharbert G, Gebhardt K, Sow Z, Duris M, Deusch E, Kozek-Langenecker S (2007) Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis, 18, 775780.
  • 74
    Silvanto M, Munsterhjelm E, Savolainen S et al. (2007) Effect of 3 g of intravenous paracetamol on post-operative analgesia, platelet function and liver enzymes in patients undergoing tonsillectomy under local anaesthesia. Acta Anaesthesiologica Scandinavica, 51, 11471154.
  • 75
    Carreia MA (2007) Drug biotransformation. In: Basic and Clinical Pharmacology. KatzungBG, ed. McGraw-Hill: New York, 5063.
  • 76
    Persky V, Piorkowski J, Hernandez E et al. (2008) Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 101, 271278.
  • 77
    Rebordosa C, Kogevinas M, Sorensen HT, Olsen J (2008) Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study. International Journal of Epidemiology, 37, 583590.
  • 78
    Forman JP, Stampfer MJ, Curhan GC (2005) Non-narcotic analgesic dose and risk of incident hypertension in US women. Hypertension, 46, 500507.
  • 79
    Kurth T, Hennekens CH, Sturmer T, Sesso HD, Glynn RJ, Buring JE, Gaziano JM (2005) Analgesic use and risk of subsequent hypertension in apparently healthy men. Archives of Internal Medicine, 165, 19031909.
  • 80
    Smith HS (2009) Potential analgesic mechanisms of acetaminophen. Pain Physician, 12, 269280.
  • 81
    Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology, 231, 232235.
  • 82
    Warner TD, Mitchell JA (2002) Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum? Proceedings of the National Academy of Sciences of the United States of America, 99, 1337113373.
  • 83
    Ayoub SS, Colville-Nash PR, Willoughby DA, Botting RM (2006) The involvement of a cyclooxygenase 1 gene-derived protein in the antinociceptive action of paracetamol in mice. European Journal of Pharmacology, 538, 5765.
  • 84
    Greco A, Ajmone-Cat MA, Nicolini A, Sciulli MG, Minghetti L (2003) Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. Journal of Neuroscience Research, 71, 844.
  • 85
    Baker FC, Driver HS, Paiker J, Rogers GG, Mitchell D (2002) Acetaminophen does not affect 24-h body temperature or sleep in the luteal phase of the menstrual cycle. Journal of Applied Physiology, 92, 16841691.
  • 86
    Hinz B, Cheremina O, Brune K (2008) Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. The Journal of the Federation of American Societies for Experimental Biology, 22, 383390.
  • 87
    Chandrasekharan NV, Dai H, Roos KLT, Evanson NK, Tomsik J, Elton TS, Simmons DL (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proceedings of the National Academy of Sciences of the United States of America, 99, 1392613931.
  • 88
    Snipes JA, Kis B, Shelness GS, Hewett JA, Busija DW (2005) Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat. Journal of Pharmacology and Experimetnal Therapeutics, 313, 668676.
  • 89
    Ouellet M, Percival MD (2001) Mechanism of acetaminophen inhibition of cyclooxygenase isoforms. Archives of Biochemistry and Biophysics, 387, 273280.
  • 90
    Schildknecht S, Daiber A, Ghisla S, Cohen RA, Bachschmid MM (2008) Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite. The Journal of the Federation of American Societies for Experimental Biology, 22, 215224.
  • 91
    Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA (2002) Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases. Proceedings of the National Academy of Sciences of the United States of America, 99, 71307135.
  • 92
    Lucas R, Warner TD, Vojnovic I, Mitchell JA (2005) Cellular mechanisms of acetaminophen: role of cyclo-oxygenase. The Journal of the Federation of American Societies for Experimental Biology, 19, 635637.
  • 93
    Bujalska M (2004) Effect of nitric oxide synthase inhibition on antinociceptive action of different doses of acetaminophen. Polish Journal of Pharmacology, 56, 605610.
  • 94
    Riedel W, Neeck G (2001) Nociception, pain, and antinociception: current concepts. Zeitschrift fur Rheumatologie, 60, 404415.
  • 95
    Godfrey L, Bailey I, Toms NJ, Clarke GD, Kitchen I, Hourani SM (2007) Paracetamol inhibits nitric oxide synthesis in murine spinal cord slices. European Journal of Pharmacology, 562, 6871.
  • 96
    Ryu YS, Lee JH, Seok JH et al. (2000) Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates. Biochemical and Biophysical Research Communications, 272, 758764.
  • 97
    Bujalska M, Gumulka WS (2001) Effect of cyclooxygenase and NO synthase inhibitors on antinociceptive action of acetaminophen. Polish Journal of Pharmacology, 53, 341350.
  • 98
    Bujalska M (2003) Effect of cyclooxygenase and NO synthase inhibitors administered centrally on antinociceptive action of acetaminophen (Part II). Polish Journal of Pharmacology, 55, 10011011.
  • 99
    Raffa RB (2002) Acetaminophen and metabolite: lack of effect on nitric oxide synthase (constitutive or inducible). Headache, 42, 237238.
  • 100
    Devane WA, Dysarz FAd, Johnson MR, Melvin LS, Howlett AC (1988) Determination and characterization of a cannabinoid receptor in rat brain. Molecular Pharmacology, 34, 605613.
  • 101
    Devane WA, HanuÅ¡ L, Breuer A et al. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 258, 19461949.
  • 102
    Fride E (2002) Endocannabinoids in the central nervous system – an overview. Prostaglandins, Leukotrienes and Essential Fatty Acids, 66, 221.
  • 103
    Raffa RB, Codd EE (1996) Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life Sciences, 59, PL37PL40.
  • 104
    Mallet C, Daulhac L, Bonnefont Jrm et al. (2008) Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia. Pain, 139, 190200.
  • 105
    Hogestatt ED, Jonsson BAG, Ermund A et al. (2005) Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. Journal of Biological Chemistry, 280, 3140531412.
  • 106
    Zygmunt PM, Chuang H-h, Movahed P, Julius D, Högestätt ED (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. European Journal of Pharmacology, 396, 3942.
  • 107
    Ralevic V, Kendall DA, Jerman JC, Middlemiss DN, Smart D (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. European Journal of Pharmacology, 424, 211219.
  • 108
    Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science, 277, 10941097.
  • 109
    De Petrocellis L, Bisogno T, Davis JB, Pertwee RG, Di Marzo V (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Letters, 483, 5256.
  • 110
    Karai L, Brown DC, Mannes AJ et al. (2004) Deletion of vanilloid receptor 1 expressing primary afferent neurons for pain control. The Journal of Clinical Investigation, 113, 1344.
  • 111
    Szallasi A, Di Marzo V (2000) New perspectives on enigmatic vanilloid receptors. Trends in Neurosciences, 23, 491497.
  • 112
    Ottani A, Leone S, Sandrini M, Ferrari A, Bertolini A (2006) The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors. European Journal of Pharmacology, 531, 280281.
  • 113
    Ovadia H, Wohlman A, Mechoulam R, Weidenfeld J (1995) Characterization of the hypothermic effect of the synthetic cannabinoid HU-210 in the rat. Relation to the adrenergic system and endogenous pyrogens. Neuropharmacology, 34, 175180.
  • 114
    Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S (2006) Paracetamol: new vistas of an old drug. CNS Drug Reviews, 12, 250.
  • 115
    Abbott FV, Hellemans KGC (2000) Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects. Behavioural Brain Research, 112, 177186.
  • 116
    Orr KK, Matson KL, Cowles BJ (2006) Nonprescription medication use by infants and children: product labeling versus evidence-based medicine. Journal of Pharmacy Practice, 19, 286294.
  • 117
    Roca-Vinardell A, Ortega-Alvaro A, Gibert-Rahola J, Mico JA (2003) The role of 5-HT1A/B autoreceptors in the antinociceptive effect of systemic administration of acetaminophen. Anesthesiology, 98, 741747.
  • 118
    Sandrini M, Pini LA, Vitale G et al. (2003) Differential involvement of central 5-HT1B and 5-HT3 receptor subtypes in the antinociceptive effect of paracetamol. Inflammation Research : Official Journal of the European Histamine Research Society, 52, 347352.
  • 119
    Pelissier T, Alloui A, Caussade F, Dubray C, Cloarec A, Lavarenne J, Eschalier A (1996) Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence. The Journal of Pharmacology and Experimental Therapeutics, 278, 814.
  • 120
    Libert F, Bonnefont J, Bourinet E et al. (2004) Acetaminophen: a central analgesic drug that involves a spinal tropisetron-sensitive, non-5-HT(3) receptor-mediated effect. Molecular Pharmacology, 66, 728734.
  • 121
    Pini LA, Sandrini M, Vitale G (1996) The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. European Journal of Pharmacology, 308, 3140.
  • 122
    Pini LA, Vitale G, Ottani A, Sandrini M (1997) Naloxone-reversible antinociception by paracetamol in the rat. The Journal of Pharmacology and Experimental Therapeutics, 280, 934940.
  • 123
    Courade JP, Besse D, Delchambre C et al. (2001) Acetaminophen distribution in the rat central nervous system. Life Sciences, 69, 14551464.
  • 124
    Srikiatkhachorn A, Tarasub N, Govitrapong P (1999) Acetaminophen-induced antinociception via central 5-HT(2A) receptors. Neurochemistry International, 34, 491498.
  • 125
    Sandrini M, Vitale G, Ruggieri V, Pini LA (2007) Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats. Inflammation Research : Official Journal of the European Histamine Research Society, 56, 139142.
  • 126
    Tjolsen A, Lund A, Hole K (1991) Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems. European Journal of Pharmacology, 193, 193201.
  • 127
    Pelissier T, Alloui A, Paeile C, Eschalier A (1995) Evidence of a central antinociceptive effect of paracetamol involving spinal 5HT3 receptors. Neuroreport, 6, 15461548.
  • 128
    Alloui A, Pelissier T, Dubray C, Lavarenne J, Eschalier A (1996) Tropisetron inhibits the antinociceptive effect of intrathecally administered paracetamol and serotonin. Fundamental & Clinical Pharmacology, 10, 406407.
  • 129
    Courade JP, Chassaing C, Bardin L, Alloui A, Eschalier A (2001) 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats. European Journal of Pharmacology, 432, 17.
  • 130
    Pickering G, Loriot MA, Libert F, Eschalier A, Beaune P, Dubray C (2006) Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clinical Pharmacology and Therapeutics, 79, 371378.
  • 131
    Pickering G, Esteve V, Loriot MA, Eschalier A, Dubray C (2008) Acetaminophen reinforces descending inhibitory pain pathways. Clinical Pharmacology and Therapeutics, 84, 4751.
  • 132
    Raffa RB, Stone DJJR, Tallarida RJ (2000) Discovery of “self-synergistic” spinal/supraspinal antinociception produced by acetaminophen (paracetamol). The Journal of Pharmacology and Experimental Therapeutics, 295, 291.
  • 133
    Raffa RB, Walker EA, Sterious SN (2004) Opioid receptors and acetaminophen (paracetamol). European Journal of Pharmacology, 503, 209210.