†Consultant Physician, Watford General Hospital, Vicarage Road, Watford, Herts. WD1 8HB, UK.
The problem of rickets in UK Asians
Version of Record online: 28 MAR 2008
Journal of Human Nutrition and Dietetics
Volume 2, Issue 2, pages 105–116, April 1989
How to Cite
Clements, M. R. (1989), The problem of rickets in UK Asians. Journal of Human Nutrition and Dietetics, 2: 105–116. doi: 10.1111/j.1365-277X.1989.tb00015.x
- Issue online: 28 MAR 2008
- Version of Record online: 28 MAR 2008
- Asian rickets;
- vitamin D;
- enterohepatic circulation;
- calcium metabolism disorders;
- 25-hydroxyvitamin D;
- 25-dihydroxyvitamin D
A large body of work relating to the occurrence of rickets in UK Asians is reviewed. Several theories of the aetiology of this condition are shown to be untenable: it is not exclusively a function of sunlight deprivation or of darker pigmentation; nor is it simply due to phytate-induced losses of calcium from the gut. Asian rickets, however, is associated with a high consumption of cereals, and experiments with rats have suggested a mechanism. In the absence of adequate vitamin D from sunlight, the low-calcium, high cereal intake of the UK Asian population may induce a state of mild secondary hyperparathyroidism which enhances the destruction of vitamin D and leads to a progressive reduction in vitamin D status and, ultimately, to the development of clinical rickets.