Determinants of carotid intima-media thickness: a population-based ultrasonography study in Eastern Finnish men
Article first published online: 4 AUG 2009
1991 Blackwell Publishing Ltd
Journal of Internal Medicine
Volume 229, Issue 3, pages 225–231, March 1991
How to Cite
SALONEN, R. and SALONEN, J. T. (1991), Determinants of carotid intima-media thickness: a population-based ultrasonography study in Eastern Finnish men. Journal of Internal Medicine, 229: 225–231. doi: 10.1111/j.1365-2796.1991.tb00336.x
- Issue published online: 4 AUG 2009
- Article first published online: 4 AUG 2009
- Received 19 March 1990, accepted 14 August 1990.
- population studies;
Abstract. We investigated the determinants of maximal intima-media thickness of common carotid arteries in a population-based sample of 1224 Eastern Finnish men aged 42, 48, 54 or 60 years. A high-resolution B-mode ultrasonographic examination was performed as part of the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). The maximal intima-media thickness (IMT) varied between 0.48 mm and 4.09 mm (mean value ± SD, 0.94 mm ± 0.38 mm). Age (standardized partial coefficient, beta = 0.238, P < 0.0001), ambulatory pulse pressure (beta = 0.130, P < 0.0001), cigarette-years of smoking (beta = 0.125, P < 0.0001), serum LDL cholesterol concentration (beta = 0.125, P < 0.0001), history of ischaemic heart disease (beta = 0.125, P < 0.0001), pre-exercise systolic blood pressure (beta = 0.070, P = 0.0113) and diabetes (beta = 0.068, P = 0.0072) were most strongly associated with IMT. This study confirms the role of systolic blood pressure, smoking and serum LDL cholesterol levels as major risk factors for increased carotid intima-media thickness.