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Determinants of carotid intima-media thickness: a population-based ultrasonography study in Eastern Finnish men

Authors


Research Institute of Public Health, University of Kuopio, P.O. Box 6, 70211 Kuopio, Finland.

Abstract

Abstract. We investigated the determinants of maximal intima-media thickness of common carotid arteries in a population-based sample of 1224 Eastern Finnish men aged 42, 48, 54 or 60 years. A high-resolution B-mode ultrasonographic examination was performed as part of the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). The maximal intima-media thickness (IMT) varied between 0.48 mm and 4.09 mm (mean value ± SD, 0.94 mm ± 0.38 mm). Age (standardized partial coefficient, beta = 0.238, P < 0.0001), ambulatory pulse pressure (beta = 0.130, P < 0.0001), cigarette-years of smoking (beta = 0.125, P < 0.0001), serum LDL cholesterol concentration (beta = 0.125, P < 0.0001), history of ischaemic heart disease (beta = 0.125, P < 0.0001), pre-exercise systolic blood pressure (beta = 0.070, P = 0.0113) and diabetes (beta = 0.068, P = 0.0072) were most strongly associated with IMT. This study confirms the role of systolic blood pressure, smoking and serum LDL cholesterol levels as major risk factors for increased carotid intima-media thickness.

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