Antibodies to neutrophil granulocyte myeloperoxidase and elastase: autoimmune responses in glomerulonephritis due to hydralazine treatment
Article first published online: 4 AUG 2009
1991 Blackwell Publishing Ltd
Journal of Internal Medicine
Volume 229, Issue 3, pages 261–265, March 1991
How to Cite
NÄSSBERGER, L., JOHANSSON, A.-C., BJÖRCK, S. and SJÖHOLM, A. G. (1991), Antibodies to neutrophil granulocyte myeloperoxidase and elastase: autoimmune responses in glomerulonephritis due to hydralazine treatment. Journal of Internal Medicine, 229: 261–265. doi: 10.1111/j.1365-2796.1991.tb00342.x
- Issue published online: 4 AUG 2009
- Article first published online: 4 AUG 2009
- Received 3 April 1990, accepted 6 September 1990.
- adverse effect;
- elastase antibodies;
- myeloperoxidase antibodies
Abstract. Autoantibodies against myeloperoxidase and elastase were found in a study of nine patients who had developed glomerulonephritis after treatment with hydralazine, but not in patients who were treated with hydralazine without side-effects. Circulating IgM isotype antibodies against myeloperoxidase, and IgM and IgG anti-elastase, were mainly present during the initial months after withdrawal of the drug. By contrast, IgG isotype antibodies against myeloperoxidase, initially found in seven patients, had increased in concentration and were present in all patients at follow-up after 4–12 years.