Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases
Article first published online: 4 AUG 2009
1994 Blackwell Publishing Ltd
Journal of Internal Medicine
Volume 236, Issue 3, pages 315–322, September 1994
How to Cite
BELL, H., SKINNINGSRUD, A., RAKNERUD, N. and TRY, K. (1994), Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases. Journal of Internal Medicine, 236: 315–322. doi: 10.1111/j.1365-2796.1994.tb00802.x
- Issue published online: 4 AUG 2009
- Article first published online: 4 AUG 2009
- Received 5 January 1994, accepted 8 March 1994
- alcoholic liver disease;
- non-alcoholic liver diseases;
- serum ferritin;
- transferrin saturation
Abstract. Objectives. To compare serum ferritin concentration and transferrin saturation in patients with alcoholic and non-alcoholic chronic liver diseases.
Design. Concecutive patients with liver diseases.
Setting. The department of internal medicine in a teaching hospital.
Subjects. Three hundred and twelve patients with different liver diseases concecutively admitted between 1987 and 1992.
Main outcome measures. Fasting serum iron, transferrin and ferritin.
Results. Serum ferritin was increased above 200 μg L−1 in all 18 patients with haemochromatosis (range 310–6500 μg L−1), in 64 of 111 alcoholics (58%) and in 30 of 137 (22%) with chronic non-alcoholic liver diseases (P < 0.01). Twelve of 111 alcoholics (11%) had serum ferritin above 1000 μg L−1 compared with one of 137 (0.7%) with chronic non-alcoholic liver diseases. In 13 alcoholics who abstained after admission, serum ferritin decreased from 1483 μg L1 ± 1134 to 388 μg L−1 ± 237 (P < 0.001) after 1 1/2 to 6 weeks. The transferrin saturation was increased above 62% in 13 of 18 patients (72%) with haemochromatosis, in 16 of 105 alcoholics (15.2%) and in three of 132 (2.3%) with chronic non-alcoholic liver disease (P < 0.01).
Conclusion. Serum ferritin is more frequently elevated in abusing patients with alcoholic liver disease than in patients with other chronic liver diseases such as autoimmune liver diseases and hepatitis C. Because serum ferritin decreases rapidly during abstinence, the measurement of ferritin for the detection of haemochromatosis in patients abusing alcohol should be postponed until the patients are abstaining. Most of the patients with increased serum ferritin have normal transferrin saturation values which can be used to separate them from haemochromatosis.