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  2. Keyword index
  • acute intermittent porphyria, 176
  • acute myocardial infarction, 244, 494
  • adenosine, 591
  • adrenergic alpha-antagonists, 548
  • ageing, 13
  • albuminuria, 76
  • alkaptonuria, 296
  • Alzheimer's disease, 517
  • amyloidosis (hereditary), 225
  • antibody, 363
  • anticoagulant(s), 313, 322, 335, 527
  • anticoagulation, 308
  • anti-DNA antibodies, 193
  • aortic valvular sclerosis, 140
  • apoptosis, 168
  • aspirin, 67, 584
  • association study, 597
  • ATPase, 517
  • atrial fibrillation, 95
  • AVPD, 479
  • benefit assessment, 426
  • BIBR 1048, 322
  • blood pressure, 46, 386
  • Body Mass Index, 251, 555
  • body size, 555
  • bone markers, 159
  • bone metabolism, 296
  • bone mineral density, 159, 296
  • bronchoalveolar lavage, 564
  • bupropion sustained release, 184
  • CAD, 479
  • cancer, 308, 353
  • candidate genes, 401
  • cardiovascular, 353
  • cardiovascular disease, 114, 386
  • cardiovascular disorders, 236
  • cardiovascular risk, 132
  • case–control study/studies, 280, 486, 548
  • cathelicidins, 197
  • cecropins, 197
  • chemokine receptors, 564
  • cholesterol metabolism, 597
  • chronic renal failure, 439
  • clinical signs, 257
  • clinical trials, 426
  • cobalamin, 343
  • coronary artery disease, 472
  • coronary heart disease, 236, 597
  • corticosteroids, 486
  • cortisol, 386, 494
  • cost-effectiveness, 426
  • Cox regression, 494
  • C-reactive protein, 132, 244
  • current smoker, 572
  • cytochrome c, 168
  • cytokine, 375
  • cytokine production, 363
  • cytomegalovirus, 472
  • daytime sleepiness, 32
  • deep vein thrombosis, 527
  • defensins, 197
  • dementia, 67
  • depression, 13
  • diabetes, 46, 114, 280, 386, 455
  • diabetes mellitus, 464, 494
  • diabetic maculopathy, 147
  • diabetic nephropathy, 147
  • diabetic retinopathy, 147
  • diagnosis, 257
  • dialysis, 132
  • dipyridamole, 591
  • direct thrombin inhibitor, 322
  • drop-out, 272
  • echocardiography, 591
  • endogenous antibiotics, 197
  • endothelin, 85
  • endothelium-dependent vasodilation, 85
  • endotoxin, 375
  • epidemiology, 353, 486
  • essential hypertension, 76
  • ethnic groups, 236
  • evidence-based medicine, 105, 426
  • factor VIIa, 313
  • factor Xa inhibitor, 335
  • familial risk, 401
  • febrile urinary tract infection, 280
  • fibrinogen, 132, 244
  • fibromuscular dysplasia, 605
  • folate, 343, 455, 504
  • fracture, 486
  • fracture risk, 572
  • functional limitation, 540
  • gastric acidity, 439
  • gastrin, 439
  • genetic polymorphisms, 140
  • genetic testing, 401
  • genetics, 401
  • geographical variation, 572
  • glomerular basement membrane, 216
  • glycaemic control, 264
  • haemoglobin A1c, 494
  • haemorrhagic stroke, 434
  • HbA1c, 264
  • health status, 540
  • heritability, 126
  • hierarchies of evidence, 105
  • high mobility group 1, 375
  • hip fractures, 548
  • homocysteine, 67, 264, 343, 455, 504
  • hormones, 13, 447
  • H. pylori, 439
  • human, 353
  • human umbilical venular endothelial cells, 375
  • hyperglycaemia, 464
  • hypertension, 46, 605
  • hyperthyroidism, 504
  • hypogonadism, 447
  • ibandronate, 159
  • immune system, 472
  • immunology, 6
  • impaired fasting glucose, 287
  • inborn errors of metabolism, 225
  • incidence, 236, 251, 287
  • inflammation, 132, 308, 375
  • innate immunity, 197
  • insomnia, 23
  • insulin, 455
  • insulin resistance, 32
  • interleukin-6, 32
  • interleukin-12, 564
  • interleukin-18 receptors, 564
  • interstitial lung disease, 193
  • investigation approach, 257
  • ion leak, 517
  • ion pumping, 517
  • ionophore, 517
  • islet cell antibodies, 251
  • left ventricular hypertrophy, 76
  • liver disease, 168
  • LL-37, 197
  • long-term treatment, 272
  • losartan, 147
  • low-dose warfarin and aspirin, 95
  • lung function, 540
  • lung T cells, 564
  • lymphocyte proliferation, 363
  • macroangiopathy, 391
  • macular oedema, 147
  • medical decision, 257
  • men, 386
  • metabolic rate, 23
  • metabolism, 6
  • metformin, 455
  • methylentetrahydrofolate reductase polymorphism, 264
  • methylmalonic acid, 343
  • microalbuminuria, 46, 76
  • miscarriage, 176
  • mood, 23
  • morbidity, 236
  • morbus Kostmann, 197
  • mortality, 479
  • multiple sclerosis, 363
  • Multiple Sleep Latency Tests, 23
  • non-diabetic, 494
  • obesity, 114, 272, 401, 555
  • obstructive lung disease, 540
  • ochronosis, 296
  • oestrogen, 85
  • once-weekly dosing, 159
  • optical coherence tomography scanning,  147
  • oral anticoagulation, 434
  • osteoporosis, 296
  • pentasaccharide, 335
  • peptide-based defence, 197
  • peptides, 13
  • peroxisome proliferator activated receptor delta, 597
  • personality, 23
  • pharmacoepidemiology, 548
  • physical examination, 257
  • plasma membrane, 517
  • platelet function, 67
  • podocyte, 216
  • polymorphism, 597
  • population, 353
  • population study, 126
  • positional cloning, 401
  • postmenopause, 85
  • PPAR, 114
  • preproghrelin, 391
  • prevention, 159
  • previous smoker, 572
  • prions, 517
  • prognosis, 479
  • progression, 584
  • prospective, 386
  • proteinuria, 216
  • psychomotor performance, 23
  • public health, 6
  • pulmonary embolism, 527
  • quantification of clinical signs, 257
  • raloxifene, 85
  • randomized controlled trial(s), 105, 184
  • recombinant nematode anticoagulant protein c2, 313
  • renal function, 391
  • renal infarction, 605
  • renin–angiotensin system, 464
  • respiratory symptoms, 540
  • restrictive lung disease, 540
  • riboflavin, 504
  • risk, 236, 353, 486
  • risk assessment, 426
  • risk factors, 126
  • sarcoidosis, 564
  • serum cholesterol, 126
  • serum γ-glutamyltransferase, 287
  • serum Japanese men, 287
  • sex hormone, 176
  • sleep, 13, 23
  • sleep apnoea, 32, 447
  • slit diaphragm, 216
  • smoking, 504, 572
  • smoking cessation, 184
  • soluble, 168
  • spirometry, 540
  • steroids, 13
  • stress, 591
  • stroke, 584
  • stroke prevention, 95
  • survey, 343
  • Sweden, 236
  • symptoms, 343
  • syndrome X, 517
  • systemic blood pressure, 464
  • systemic lupus erythematosus, 193
  • T lymphocytes, 472
  • Tarui's disease, 517
  • testosterone, 386
  • therapeutics, 426
  • thrifty genotype, 114
  • thrombolysis, 244
  • thrombosis, 308, 313
  • tissue factor, 313
  • transplantation (liver and heart), 225
  • transthyretin, 225
  • treatment attendance, 272
  • tumour necrosis factor-α, 32
  • type 1, 464
  • type 1 diabetes, 251
  • type 2 diabetes, 147, 251, 264, 287, 391
  • uremia, 132
  • urolithiasis, 605
  • usual interstitial pneumonitis, 193
  • variation, 391
  • venous thromboembolism, 527
  • very low calorie diet, 272
  • visceral obesity, 32
  • vitamin B12, 455
  • vitamin K antagonist, 322
  • vitamins, 67
  • von Willebrand factor, 85
  • waist circumference, 555
  • waist–hip ratio, 555
  • warfarin, 322, 434
  • weight gain, 184
  • withdrawal symptoms, 184
  • women, 140, 176
  • ximelagatran, 322
  • year of diagnosis, 251