Amphoterin as an extracellular regulator of cell motility: from discovery to disease

Authors

  • H. J. Huttunen,

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      Current address: Neurobiology of Disease Laboratory, MassGeneral Institute of Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

  • H. Rauvala

    1. From the Neuroscience Center, University of Helsinki, Helsinki, Finland
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Prof. Heikki Rauvala, PO Box 56 (Viikinkaari 4), University of Helsinki, FIN-00014 Helsinki, Finland (fax: 358-9-19157620; e-mail: heikki.rauvala@helsinki.fi)

Abstract.

Amphoterin is a ubiquitous and highly conserved protein previously considered solely as a chromatin-associated, nuclear molecule. Amphoterin is released into the extracellular space by various cell types, and plays an important role in the regulation of cell migration, differentiation, tumorigenesis and inflammation. This paper reviews recent research on the mechanistic background underlying the biology of secreted amphoterin, with an emphasis on the role of amphoterin as an autocrine/paracrine regulator of cell migration.

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