The PREVEND study group are: P. E. de Jong, G. J. Navis, R. T. Gansevoort, J. C. Verhave Department of Medicine, Division of Nephrology D. de Zeeuw, W. H. van Gilst, R. H. Henning Department of Clinical Pharmacology R. O. B. Gans, S. J. L. Bakker, A. J. Smit, A. M. van Roon, E. M. Stuveling Department of Medicine, Division of Vascular Medicine D. J. van Veldhuisen, H. L. Hillege, A. J. van Boven, F. W. Asselbergs, C. P. Baljé-Volkers Department of Cardiology R. P. F. Dullaart Department of Medicine, Division of Endocrinology G. J. te Meerman, G. T. Spijker Department of Medical Genetics V. Fidler, J. G. M. Burgerhof Department of Epidemiology and Statistics L. T. W. de Jong-van den Berg, M. J. Postma, J. van den Berg Department of Pharmaco-Epidemiology J. H. J. Muntinga Department of Medical Physiology, all of the University Medical Center Groningen and D. E. Grobbee Department of Epidemiology, Julius Center, Utrecht.
Sodium intake affects urinary albumin excretion especially in overweight subjects
Article first published online: 13 SEP 2004
Journal of Internal Medicine
Volume 256, Issue 4, pages 324–330, October 2004
How to Cite
Verhave, J. C., Hillege, H. L., Burgerhof, J. G. M., Janssen, W. M. T., Gansevoort, R. T., Navis, G. J., de Zeeuw, D., de Jong, P. E. and The PREVEND study group (2004), Sodium intake affects urinary albumin excretion especially in overweight subjects. Journal of Internal Medicine, 256: 324–330. doi: 10.1111/j.1365-2796.2004.01390.x
- Issue published online: 13 SEP 2004
- Article first published online: 13 SEP 2004
- cardiovascular risk factor;
- urinary sodium excretion
Objectives. To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality.
Design. Cross-sectional cohort study using linear regression analysis.
Setting. University hospital outpatient clinic.
Subjects. A cohort drawn from the general population, consisting of 7850 subjects 28–75 years of age, all inhabitants of the city of Groningen, the Netherlands. The cohort is enriched for the presence of subjects with elevated urinary albumin concentration.
Results. The results show a positive relationship between dietary sodium intake and urinary albumin excretion. The association was independent of other cardiovascular risk factors (such as sex, age, blood pressure, body mass index (BMI), waist-to-hip ratio, serum cholesterol, plasma glucose and smoking) and other food constituents (calcium, potassium and protein). The relationship between sodium intake and urinary albumin excretion was steeper in subjects with a higher BMI compared with a lower BMI.
Conclusions. Sodium intake is positively related to urinary albumin excretion. This relation is more pronounced in subjects with a higher BMI. These results suggest that high sodium intake may unfavourably influences cardiovascular prognosis especially in overweight and obese subjects.