Continuous care in the treatment of obesity: an observational multicentre study


  • A complete list of participant in the QUOVADIS study has been previously published [18].

Giulio Marchesini MD, Unit of Metabolic Diseases, ‘Alma Mater Studiorum’ University of Bologna, Policlinico S. Orsola, Via Massarenti, 9 I-40138 Bologna, Italy.
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Objectives.  To investigate weight loss and reasons for attrition in obese patients on long-term continuous care.

Design.  Observational study with 36 months of follow-up.

Setting.  Fifteen Italian obesity centres applying a continuous care model of medical treatment.

Subjects.  One thousand treatment-seeking obese subjects (785 females, median age 45.1 years, median BMI 37.4 kg m−2). Weight loss expectations were systematically recorded at baseline.

Interventions.  An initial intensive treatment period (3–6 months) was followed by a less intensive continuous care (a follow-up control every 2–4 months).

Main outcome measures.  Attrition, reasons for treatment interruption and BMI change. Data were recorded by telephone interview in dropouts.

Results.  Only 157 patients (15.7%) were in continuous treatment at 36 months. The main reasons of attrition were logistics, unsatisfactory results and lack of motivation. The only basal predictor for continuous care was lower Expected One-Year BMI Loss (P = 0.016). The probability of dropout increased systematically for any 5% expected BMI loss (Hazard ratio, 1.05; 96% confidence interval, 1.01–1.09). The mean percentage weight loss was greater in continuers (5.2% vs. 3.0% in dropouts; P = 0.016). However, the dropouts satisfied with the results or confident to lose additional weight without professional help reported a mean weight loss of 9.6% and 6.5% respectively.

Discussion.  Continuous care produces long-term weight loss only in a subgroup of obese patients seeking treatment in medical centres. The finding that subgroups of dropouts report long-term weight loss has implication for the treatment of obesity.