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Tumour necrosis factor-α in human adipose tissue – from signalling mechanisms to clinical implications
Article first published online: 2 AUG 2007
DOI: 10.1111/j.1365-2796.2007.01854.x
Additional Information
How to Cite
Rydén, M. and Arner, P. (2007), Tumour necrosis factor-α in human adipose tissue – from signalling mechanisms to clinical implications. Journal of Internal Medicine, 262: 431–438. doi: 10.1111/j.1365-2796.2007.01854.x
Publication History
- Issue published online: 2 AUG 2007
- Article first published online: 2 AUG 2007
- Abstract
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Keywords:
- adipose tissue;
- cytokine;
- inflammation;
- lipolysis;
- macrophage
Abstract.
From its initial implication in the development of cachexia in the early 1980s, it is now almost 15 years ago that tumour necrosis factor-alpha (TNF-α) was first shown to be involved in the development of insulin resistance in obesity. Since the original findings in mice, a wealth of data has been obtained in a variety of settings and species. This intensive research has demonstrated both similarities and differences between rodents and humans regarding the molecular mechanisms and metabolic consequences of TNF-α overexpression. This review will focus on the role of TNF-α in human white adipose tissue with particular emphasis on its regulation of lipolysis – an important pathway in adipocytes which is linked to insulin-resistant phenotypes in obesity and the metabolic syndrome.