Present address: Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA
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SIRT6 in DNA repair, metabolism and ageing
Article first published online: 21 JAN 2008
DOI: 10.1111/j.1365-2796.2007.01902.x
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How to Cite
Lombard, D. B., Schwer, B., Alt, F. W. and Mostoslavsky, R. (2008), SIRT6 in DNA repair, metabolism and ageing. Journal of Internal Medicine, 263: 128–141. doi: 10.1111/j.1365-2796.2007.01902.x
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Present address: Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA
Publication History
- Issue published online: 21 JAN 2008
- Article first published online: 21 JAN 2008
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Keywords:
- ageing;
- DNA damage;
- metabolism
Abstract.
Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1-like signalling. In addition, homologs of yeast Sir2 – the sirtuins – regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [Cell (2006) 124:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.