• 1
    Fulcher KY, White PD. Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome. Br Med J 1997; 314: 164752.
  • 2
    Wallman KE, Morton AR, Goodman C, Grove R, Guilfoyle AM. Randomised controlled trial of graded exercise in chronic fatigue syndrome. Med J Aust 2004; 180: 4448.
  • 3
    Powell P, Bentall RP, Nye FJ, Edwards RH. Randomised controlled trial of patient education to encourage graded exercise in chronic fatigue syndrome. Br Med J 2001; 322: 38790.
  • 4
    Edmonds M, McGuire H, Price J. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev 2004; 3: CD003200 pub2. DOI: 10.1002/14651858.CD003200.pub2.
  • 5
    Jammes Y, Steinberg JG, Mambrini O, Brégeon F, Delliaux S. Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. J Intern Med 2005; 257: 299310.
  • 6
    Lapp CW. Exercise limits in chronic fatigue syndrome. Am J Med 1997; 103: 834.
  • 7
    Bazelmans E, Blijenberg G, Voeten MJM, Van Der Meer JWM, Folgering H. Impact of a maximal exercise test on symptoms and activity in chronic fatigue syndrome. J Psychosom Res 2005; 59: 2018.
  • 8
    Black CD, O’Connor PJ, McCully KK. Increased daily physical activity and fatigue symptoms in chronic fatigue syndrome. Dyn Med 2005; 4: 3. DOI: 10.1186/1476-5918-4-3.
  • 9
    Knoop H, Bleijenberg G, Gielissen MFM, Van Der Meer JWM, White PD. Is a full recovery possible after cognitive behavioural therapy in chronic fatigue syndrome? Psychother Psychosom 2007; 76: 1716.
  • 10
    Sorensen B, Streib JE, Strand M et al. Complement activation in a model of chronic fatigue syndrome. J Allergy Clin Immunol 2003; 12: 397403.
  • 11
    Ohashi K, Yamamoto Y, Natelson BH. Activity rhythm degrades after strenuous exercise in chronic fatigue syndrome. Physiol Behav 2002; 77: 3944.
  • 12
    Hawk C, Jason LA, Torres-Harding S. Differential diagnosis of chronic fatigue syndrome and major depressive disorder. Int J Behav Med 2006; 13: 24451.
  • 13
    Whistler T, Jones JF, Unger ER, Vernon SD. Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjects. BMC Physiol 2005; 5: 5. DOI: 10.1186/1472-6793-5-5.
  • 14
    Nijs J, Almond F, De Becker P, Truijen S, Paul L. Can exercise limits prevent post-exertional malaise in chronic fatigue syndrome? An uncontrolled clinical trial. Clin Rehabil 2008; 22: 42635.
  • 15
    Nijs J, Paul L, Wallman K. Chronic fatigue syndrome: an approach combining self-management with graded exercise to avoid exacerbations. J Rehabil Med 2008; 40: 2417.
  • 16
    Sorensen B, Jones JF, Vernon SD, Rajeevan MS. Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome. Mol Med 2009; 15: 3442.
  • 17
    Meeus M, Nijs J, McGregor N et al. Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage, and elastase activity and their clinical relevance. In Vivo 2008; 22: 11522.
  • 18
    Demettre E, Bastide L, D’Haese A et al. Ribonuclease L proteolysis in peripheral blood mononuclear cells of Chronic Fatigue Syndrome patients. J Biol Chem 2002; 277: 3574651.
  • 19
    Englebienne P, Herst CV, De Smet K, D’Haese A, De Meirleir K. Interactions between RNase L ankyrin-like domain and ABC transporters as a possible origin for pain, ion transport, CNS and immune disorders of chronic fatigue immune dysfunction syndrome. J Chronic Fatigue Syndr 2001; 8: 839.
  • 20
    Nijs J, Meeus M, McGregor NR et al. Chronic fatigue syndrome: exercise performance related to immune dysfunction. Med Sci Sports Exerc 2005; 37: 164754.
  • 21
    Nijs J, Vaes P, McGregor N, Van Hoof E, De Meirleir K. Psychometric properties of the Dutch Chronic Fatigue Syndrome – Activities and Participation Questionnaire (CFS-APQ). Phys Ther 2003; 83: 44454.
  • 22
    Ji R-R, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci 2003; 26: 696705.
  • 23
    Wolf G, Yirmiya R, Goshen I et al. Impairment of interleukin-1 (IL-1) signalling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects. Pain 2003; 104: 47180.
  • 24
    Al’Absi M, Petersen KL, Wittmers LE. Adrenocortical and hemodynamic predictors of pain perception in men and women. Pain 2002; 96: 197204.
  • 25
    Lariviere WR, Melzack R. The role of corticotropin-releasing factor in pain and analgesia. Pain 2000; 84: 112.
  • 26
    Cleare AJ. The HPA axis and the genesis of chronic fatigue syndrome. Trends Endocrinol Metab 2004; 15: 5553.
  • 27
    Van Den Eede F, Moorkens G, Van Houdenhove B, Cosyns P, Claes SJ. Hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome. Neuropsychobiology 2007; 55: 11220.
  • 28
    Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathology of stress-related disorders. Am J Psychiatry 2003; 160: 155465.
  • 29
    Van Houdenhove B, Egle UT. Fibromyalgia: a stress disorder? Piecing the biopsychosocial puzzle together. Psychother Psychosom 2004; 73: 26775.
  • 30
    Fukuda K, Strauss SE, Hickie I et al. The Chronic Fatigue Syndrome, a comprehensive approach to its definition and study. Ann Intern Med 1994; 121: 9539.
  • 31
    Wolfe F, Smythe HA, Yunus MB et al. The American College of Rheumatology 1990 Criteria for the classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990; 33: 16072.
  • 32
    Sargent C, Scroop GC, Nemeth PM, Burnet RB, Buckley JD. Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome. Med Sci Sports Exerc 2002; 34: 516.
  • 33
    De Becker P, Roeykens J, Reynders M, McGregor N, De Meirleir K. Exercise capacity in chronic fatigue syndrome. Arch Int Med 2000; 160: 32707.
  • 34
    De Becker P, McGregor N, De Meirleir K. A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome. J Intern Med 2001; 250: 23440.
  • 35
    Nijs J, Aerts A, De Meirleir K. Generalized joint hypermobility is more common in chronic fatigue syndrome than in healthy controls. J Manipulative Physiol Ther 2006; 29: 329.
  • 36
    Nijs J, Thielemans A. Kinesiophobia and symptomatology in chronic fatigue syndrome: a psychometric study of two questionnaires. Psychol Psychother 2008; 81: 27383.
  • 37
    Ware J, Snow K, Kosinski M, Gandek B. SF-36 Health Survey Manual and Interpretation Guide. Boston, MA: New England Medical Center, The Health Institute, 1993.
  • 38
    Wells K, Stewart A, Hays R et al. The functioning and well-being of depressed patients. Results from the medical outcomes study. JAMA 1989; 262: 9149.
  • 39
    McHorney CA, Ware JE, Lu JFR, Sherbourne CD. The MOS 36-item Short Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patients groups. Med Care 1994; 32: 4066.
  • 40
    Nijs J, Vaes P, Van Hoof E, De Becker P, McGregor N, De Meirleir K. Activity limitations and participation restrictions in patients with chronic fatigue syndrome – construction of a disease specific questionnaire. J Chronic Fatigue Syndr 2002; 10: 323.
  • 41
    Vercoulen JHMM, Swanink CMA, Fennis JFM, Galama JMD, Van Der Meer JWM, Bleijenberg G. Dimensional assessment of chronic fatigue syndrome. J Psychosom Res 1994; 38: 38392.
  • 42
    Vercoulen JHMM, Alberts M, Bleijenberg G. De checklist individual strength (CIS). Gedragstherapie 1999; 32: 1316.
  • 43
    Wallman K, Goodman C, Morton A, Grove R, Dawson B. Test–retest reliability of the Aerobic Power Index Test in patients with chronic fatigue syndrome. J Chronic Fatigue Syndr 2003; 11: 1932.
  • 44
    Wallman K, Goodman C, Morton A, Grove R, Dawson B. Test–retest reliability of the aerobic power index component of the tri-level fitness profile in a sedentary population. J Sci Med Sport 2003; 6: 44354.
  • 45
    Nijs J, Demol S, Wallman K. Can submaximal exercise variables predict peak exercise performance in women with chronic fatigue syndrome? Arch Med Res 2007; 38: 3503.
  • 46
    Telford R, Minikin B, Hahn A, Hooper L. A simple method for the assessment of general fitness: the tri-level profile. Aust J Sci Med Sport 1989; 21: 69.
  • 47
    Meyer T, Georg T, Becker C, Kindermann W. Reliability of gas exchange measurements from two different spiroergometry systems. Int J Sports Med 2001; 22: 5937.
  • 48
    Finn KJ, Specker B. Comparison of Actiwatch activity monitor and Children’s Activity Rating Scale in children. Med Sci Sports Exerc 2000; 32: 17947.
  • 49
    Cook DB, Nagelkirk PR, Peckerman A, Poluri A, Mores J, Natelson BH. Exercise and cognitive performance in chronic fatigue syndrome. Med Sci Sports Exerc 2005; 37: 14607.
  • 50
    Robinson M, Gray SR, Watson MS et al. Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome. Scand J Med Sci Sports 2009; 13: 19.
  • 51
    Jammes Y, Steinberg JG, Delliaux S, Brégeon F. Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. J Intern Med 2009; 266: 196206.
  • 52
    Cannon JG, Angel JB, Ball RW, Abad LW, Fagioli L, Komaroff AL. Acute phase responses and cytokine secretion in chronic fatigue syndrome. J Clin Immunol 1999; 19: 41421.
  • 53
    Player MR, Torrence PF. The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation. Pharmacol Ther 1998; 78: 55113.
  • 54
    Nijs J, Frémont M. Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state-of-the-art and therapeutic implications. Expert Opin Ther Targets 2008; 12: 2819.